Endocrine Abstracts (2010) 22 P499

The unfavourable effect of oral contraceptive pills on the metabolic parameters in women with polycystic ovary syndrome

Olgierd Gluszak1, Urszula Stopinska-Gluszak1 & Romuald Debski2

1Endocrinology CMKP, Warsaw, Poland; 2Gynecology and Obstetrics CMKP, Warsaw, Poland.

The polycystic ovary syndrome (PCOS) is a common endocrinopathy (6–8%) of the female population in the reproductive age. It is characterised by oligomenorrhoea, hyperandrogenism and the presence of polycystic ovary. PCOS is also associated with the disturbance of carbohydrate and lipid metabolism. The basic treatment consists of the application of diet, physical activities and the use of hormonal therapy. The aim of our study was to investigate the effect of three months treatment with oral contraceptive pills (OCP) consisting of desogestrel and ethinyloestradiol on the selected metabolic parameters in 100 women with PCOS. Results: After 3 months treatment we observed a significant (P<0.05) reduction of total testosterone, androstenedione, 17-hydroxyprogesterone (17OH-Prg), estradiol, LH, FSH, prothrombin time (PT), international normalized ratio (INR) and an average ovarian volume; contrary to a significant (P<0.05) increase of sex hormone binding globulin (SHBG), high-sensitivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (OB), total cholesterol, LDL-cholesterol, triglycerides, fibrinogen, prothrombin index (QUICK index) and a insulin level during the glucose tolerance test.

Conclusions: The use of OCP consisting of desogestrel and ethynyloestradiol can play an effective role in the treatment of PCOS but simultaneously brings the unfavourable effects on coagulatory and metabolic parameters such us carbohydrate and lipid metabolism and can provoke faster arteriosclerosis.

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