Endocrine Abstracts (2010) 22 P745

Effectiveness of consevator treatment (antithyroidiennes and thyroxine) on the autonomous nodule, toxic adenoma, and Plummer's disease (multinodular hyperthyroideous Goiter)

José Suárez-Lledó

Hospital de León, (Ambulatorio Condesa) Sacyl, León, Spain.

Objective: The goal of this paper is to investigate the effectiveness of antithyroidiennes, associated or not, with the thyroid hormone.

Material and methods: Patients and their clinical histories were examined when each ambulatory patient was personally visited, for one year, by the author. 156 cases were examined (16 males and 140 females). The diagnoses were based on anamnesis, clinical exploration, TSH + thyroid hormone and bioquim determinations and gammagraphie. Evolution was controlled by palpation, thorax radiographies and, occasionally, ultrasonography.

Evolution was considered good when compensation was achieved without goiter or antithyroidien dosis increase, very good when the thyroid volume decreased, excellent if the dosis and volume decreased, and bad when the volume and/or dosis increased progressively.

Results: Autonomous Nodule, Toxic Adenoma: (61 patients, nine males, 52 females, mean treatment time 9.12 years S.D. 5.28, mean of age at diagnosis 60, SD 12.374) 6 were treated initially by I131, 2 by surgery and the rest by the procedures, and with the results told below:

Among treated euthyroidiennes patients three had good evolution, four very good, and eight excellent, none bad, among non-treated euthiroidiennes four had good evolution, four very good, none bad and none excellent, among hyoerthyroidiennes four patients had good evolution, very good nine and excellent 17, none bad evolution.

Total effectiveness, 100% in both cases. The treated group had the best results among euthyroidien patients, due to ‘excellent degree’ (P<0.05).

Plummer’s disease: (95 patients seven males and 88 females, mean treatment time 8.18 years S.D. 8.64. mean of age at diagnosis 58.26, S.D 22.58) 2 were treated initially by I131 and 3 by surgery, the rest by the procedures, and with the results told below:

Among euthyroidiennes treated patients 3 had good evolution, very good 4, and excellent 6, among non-treated euthyroidiennes 2 had bad evolution, and 2 very good, among hyperthyroidiennes 5 had bad evolution, 17 good evolution, 4 very good and 46 excellent.

Total effectiveness in the treated euthyroidienne group was 100%, in the non-treated, 50% and in hyperthyroidiennes, 92.4%. The treated group had the best results (P<0.05) among the euthyroidien patients.

Conclusion: The better effectiveness in the treated groups with respect to the non-treated groups must be put down to drug effect. The high degree of conservator treatment effectiveness makes this type of treatment absolutely reliable, constituting a very good option without the problems of surgical or I131 procedures.

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