Endocrine Abstracts (2010) 22 P791

Is there a relationship between colonic polyps and thyroid nodules?

Hüseyin Savas Gokturk1, Cevdet Duran2, Mustafa Kulaksizoglu2, Gülhan Kanat Unler1, Mustafa Erbayrak1, Guven Ozkaya3, Baris Onder Pamuk2 & Mustafa Sait Gonen4

1Department of Gastroenterology, Konya Research Hospital, Baskent University, Konya, Turkey; 2Division of Endocrinology, Konya Education and Research Hospital, Konya, Turkey; 3Department of Biostatistic, Medical Faculty, Uludag University, Bursa, Turkey; 4Division of Endocrinology, Medical Faculty, Selcuk University, Konya, Turkey.

Aim: Colonic polyps and thyroid nodules are common diseases and frequency increases with age. In the literature, there is no study investigating the relationship between colonic polyps and thyroid nodules. Therefore, this study was designed to investigate thyroid nodule frequency in patients who have colonic polyps.

Material and methods: Sixty-six patients with colonic polyps and 146 patients without colonic polyps enrolled in the study. Age and sex matched control group was composed from patients without colonic polyps. Colonoscopic examinations, thyroid ultrasonographies were performed in all patients and TSH, fT4 levels were measured.

Results: Male/female ratio in polyp and control groups were 40/26 vs 68/78 respectively (P=0.058). Mean patient ages were similar in both groups (53.3±11.4 vs 51.8±11.4, P=0.373). Thyroid nodule was detected in 44 (66.7%) patients in polyp group and 61 (41.8%) in controls (P=0.001). Forty-six patients had single polyp, 9 had 2 polyps, 7 had 3 and 4 had 4 or more polyps. Most of them localized in rectosigmoidal region. Histopathological examination revealed adenomateous polyp in 36 patients, hyperplastic polyp in 20 patients, and mixed type in 10 patients. Mean TSH levels were lower in the polyp group than controls (1.17±0.95 vs 1.54±1.3, P=0.002, respectively). In 95 patients, number of nodules were lower than 5 and in 10 patient 5 or more. Thyroid nodules were >10 mm in 34 patients.

Conclusion: Thyroid nodules were detected more common in patients with colonic polyps. Further studies are needed to clarify this coexistence.

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