Endocrine Abstracts

Background: Premature pubic hair development, with or without manifestations of androgen production, is a common clinical presentation. Premature adrenarche (PA) needs to be differentially diagnosed from congenital adrenal hyperplasia (CAH) and may be associated with early development of puberty.Aim: To study the characteristics at presentation, endocrine profile and outcome of patients who presented with premature pubic hair development. We studied retr...

Introduction: The UK has seen a steady rise in childhood obesity over the last 30 years, with nearly a third of children aged 2–15 now overweight or obese. Childhood obesity represents a significant health burden, costing the NHS many millions of pounds.Aim: The aim of this study was to investigate the knowledge, perception and actions of obese patients at the Royal Manchester Children’s Hospital (RMCH), to guide recommendations for improving t...

Background: Hyperthyroidism is a significant medical condition in paediatric patients with serious health consequences. Optimal treatment remains debatable.Objective: To review 23 years’ experience of paediatric hyperthyroidism in the West of Scotland.Methods: Case notes of patients treated for thyrotoxicosis in Glasgow, Paisley, Ayrshire and Lanarkshire from 1987 until 2009 inclusive were retrospectively reviewed. Patients wi...

Background: Klinefelter syndrome (KS) is the commonest sex chromosomal disorder. Characteristic features include male phenotype with hypogonadism and progressive testicular failure, gynaecomastia and learning difficulties. The association between mediastinal germ cell tumours (GCT-M) and KS is well established, with KS occurring in 20% of GCT-M patients and the reported incidence of GCT-M in KS being 1.5 per 1000 (Nichols, 1991). Genital anomalies are also known to be rarely o...

Introduction: The age range at diagnosis, complexity of the syndrome and the sensitive and emotional nature of the issues involved in a diagnosis of Turner Syndrome (TS) present specific challenges for health professionals in sharing information with girls and their families. However little is known about the perceived information needs of parents and there has been no study of the views of girls with TS.Methods: A qualitative design was employed to expl...