Searchable abstracts of presentations at key conferences in endocrinology
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38th Meeting of the British Society for Paediatric Endocrinology and Diabetes

Speaker Abstracts

Symposium 1 – Transition and Therapeutics

ea0024s15 | Symposium 1 – Transition and Therapeutics | BSPED2010

GH replacement into adult life

Gleeson H

GH deficiency (GHD) has implications throughout the lifespan. In childhood, reduced linear growth is the primary consequence of untreated GHD, while in adulthood, untreated GHD is associated with a number of abnormalities. The phenotype of GHD in adulthood differs depending on timing of onset. Childhood onset (CO) patients have reduced bone mineral content (BMC) and lean body mass (LBM) despite GH replacement therapy (GHRT) during childhood compared with adult onset. These dif...

ea0024s16 | Symposium 1 – Transition and Therapeutics | BSPED2010

Sex hormone replacement and fertility for adolescents and young adults: who needs it and how should it be done?

Zacharin Margaret

Major changes in paediatric and adult medical practice have been seen over recent decades with increased prevalence of and longevity in chronic diseases, a marked increase in organ transplantation, rapid increases in recognition of new genetic disorders associated with altered gonadal function. Along with these changes has come recognition of the pivotal importance of adolescent bone mass accrual, to decrease the impact of adult bone loss for those who have a chronic medical c...

ea0024s17 | Symposium 1 – Transition and Therapeutics | BSPED2010

Steroid replacement

Ross R J M

Cortisol secretion follows a distinct circadian rhythm, with circulating levels low at sleep onset, beginning to rise between 0200 and 0400 h, peaking within an hour of waking and then declining through the day. This circadian rhythm is determined by the central endogenous clock (pacemaker) of the hypothalamic–pituitary–adrenal (HPA) axis, located in the hypothalamic supra-chiasmatic nucleus. The HPA axis plays an important role in maintaining alertness and modulatin...