Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2011

Young Endocrinologists Session

Young endocrinologists’ prize lectures

ea0025yep1.1 | Young endocrinologists’ prize lectures | SFEBES2011

New insights into glucocorticoid receptor function

Matthews Laura

The current model of glucocorticoid receptor (GR) action is well established, whereby GR remains inactive in the cytoplasm until bound by ligand, then rapidly translocates to the nucleus to regulate target genes. However, our recent observations challenge the simplicity of this model and suggest a greater range of GR action.We have identified a novel pathway in which the GR is recruited to the plasma membrane through binding to the lipid raft marker cave...

ea0025yep1.2 | Young endocrinologists’ prize lectures | SFEBES2011

Clinical, genetic and molecular characterisation of patients with familial isolated pituitary adenomas (FIPA)

Chahal H

There is increasing recognition that pituitary adenomas may occur in a familial setting, and a number of families have been identified to have familial isolated pituitary adenoma (FIPA), without features of the MEN1 syndrome, Carney complex, or other known familial disorders. Heterozygote germline mutations were identified in a gene encoding AIP (aryl-hydrocarbon receptor interacting protein) in some FIPA families. We have characterised our unique large collection of 140 famil...