Endocrine Abstracts

Our understanding of the genetic abnormalities associated with thyroid cancers has grown significantly over the past decade. Thus, papillary thyroid cancers (PTC) have non-overlapping activating mutations genes encoding the growth factor receptors RET or NTRK, the three isoforms of RAS, or of BRAF, which altogether are found in ~70% of cases. In addition, mutations of effectors in the phosphoinositol-3-kinase (PI3K) pathway are present at various stages of the disease, but in ...

James A Fagin, Memorial Sloan-Kettering Cancer Center, New York, USA. AbstractJames A. Fagin is Chief of the Endocrine Service and a Member of the Human Oncology and Pathogenesis Program at Memorial Sloan-Kettering Cancer Center in New York, and a Professor of Medicine at Weill Medical College of Cornell University. He was formerly the James Heady Professor of Medicine and Director of the Division of Endocrinology and...