Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 25 P107

SFEBES2011 Poster Presentations Clinical biochemistry (82 abstracts)

Study of serum prolactin and cardiovascular risk in patients with type 2 diabetes mellitus

Hesham Elgayar , Manal Abu-Shady , Iman Zaki , Mona Abdelsalam & Alyaa Elsherbeny


Ain Shams University, Cairo, Egypt.


Background: Prolactin is an identified marker associated with atherosclerosis. Atherosclerotic process and hence the macrovascular complications are causes for high mortality and morbidity rates among people with diabetes.

Aim: To assess the relationship between serum prolactin and cardiovascular risk in patients with acute myocardial infarction (AMI) and patients with type 2 diabetes mellitus.

Subjects and methods: A case–control study was done in Ain Shams University Hospitals, Cairo, Egypt; serum prolactin was determined in 20 non-diabetic (group 1) and 20 diabetic (group 3) male patients within 24 h of the onset of AMI and after 2 weeks. Twenty type 2 diabetic male patients without AMI and 15 healthy age and sex-matched controls represented (group 2 and group 4, respectively). The inflammatory marker hs-CRP was also measured in the studied population.

Results: Serum prolactin was significantly higher among non-diabetic (27.52±6.75 ng/ml) and diabetic patients with AMI (21.05±6.93 ng/ml) compared to the control group (11.3±2.7575 ng/ml, P<0.01) while the diabetic patients without AMI showed insignificant difference (12.2±3.15 ng/ml) with the control group (P=1). Group1 showed minimal decline in serum prolactin level 2 weeks after the onset of AMI (22.36±4.26 ng/ml) but still was significantly higher than the control group (P<0.01) while group3 showed marked decline (9.15±2.89 ng/ml) and showed insignificant difference with the control group (P=0.67). Serum prolactin showed significant positive correlation with hs-CRP among patients with AMI whether diabetic (r=0.679, P=0.001) or non diabetic (r=0.593, P=0.006).

Conclusion: Hyperprolactinemia may be associated with increased risk of myocardial infarction but the levels of prolactin are variable among diabetics. In addition, the increase in both prolactin and hs-CRP increases the atherosclerotic process and hence the macrovascular complications revealing a new mechanism for atherosclerosis in diabetics.

Key words: Prolactin, acute myocardial infarction, atherosclerosis, diabetes.

Abbreviations: AMI: acute myocardial infarction.

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