Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 25 P127

SFEBES2011 Poster Presentations Diabetes, metabolism and cardiovascular (48 abstracts)

Utility of glycated haemoglobin in diagnosing prediabetes in Asian Indians- A Community Survey: Chandigarh Urban Diabetes Study (CUDS) group

Ravikumar Padala , Anil Bhansali , Rama Walia , M Ravikiran , G Sunder , Shobhit Bhansali , Sanjay Bhadada & Pinaki Dutta


Postgraduate Institute of Medical Education and Research, Chandigarh, India.


Aim: To determine the HbA1c cut-offs for diagnosis of prediabetes based on isolated IFG, isolated IGT and both IFG and IGT.

Methods: Cross-sectional randomized population survey involving 2368 adults, aged ≥20 years. HbA1c was measured on a Bio-Rad 10 system in 1972 subjects.

Results: Among 1972 studied subjects, 329 were detected to have prediabetes based on isolated IFG in 125 (6.3%), isolated IGT in 141 (7.1%) and both in 63 (3.2%) of subjects. The optimal HbA1c cut-off for diagnosis of prediabetes based on IFG criteria (6.1 to <7 mmol/l) was 5.5% which had a sensitivity of 67%, specificity of 52% with accuracy of 45%, and for 2 h PG (7.8 to <11.1 mmol/l), it was 5.7% with sensitivity, specificity and accuracy of 67, 67 and 59%, respectively. Subjects who had both IFG and IGT had optimal HbA1c cut-off of 5.7% with sensitivity, specificity and accuracy of 69, 60 and 57%, respectively. One hundred and thirty-four subjects (6.8%) were newly detected to have diabetes and HbA1c cut-off of 6.1% had an optimal sensitivity and specificity of 81% each with accuracy of 77% for diagnosis of diabetes.

Conclusions: HbA1c between 5.5 and 6% corresponds to the presence of prediabetes in Asian Indians.

Article tools

My recent searches

No recent searches.