Endocrine Abstracts

Introduction: Recent studies suggest that mild hyponatremia is associated with fractures, but prospective studies are lacking.Aim: Our aim was to study whether hyponatremia is associated with fractures, falls and/or bone mineral density (BMD).Methods: Five thousand two hundred and eight elderly men and women with serum sodium assessed at baseline were included from the prospective, population-based Rotterdam Study. The following da...

The calcium receptor (CaR) participates in Ca2+ and Mg2+ metabolism at the parathyroid gland and the kidney. Cinacalcet, a calcimimetic, increases the sensitivity of CaR and has been introduced for the treatment of patients with primary hyperparathyroidism (PHPT). However, there are no data for the influence of cinacalcet on serum Mg2+ levels in the literature.Aim: To evaluate the effect of cinacalcet treatment on magnesi...

Objective: To describe the evolution of neurobehavioral and cognitive symptoms in patients with primary hyperparathyroidism as measured by mini-mental state (MMS), Hamilton’s anxiety and depression scale (HADS) and Clock tests. Scores were also compared with biochemical data.Methods: The Swiss primary hyperparathyroidism (PHPT) Cohort Study is an ongoing, prospective, non-interventional national project collecting clinical, biochemical and outcome d...

Fetal exposure to environmental estrogens may contribute to hypofertility and/or to testicular germ cell cancer. However, many of these endocrine disruptors have only a weak affinity for the classical ERs and other mechanisms have been suggested. Bisphenol A, a chemical poluttant, used as monomer to manufacture polycarbonate plastic, released from lining canned food or beverages or from dental sealants, was able to promote human testicular seminoma cell (JKT-1) proliferation <...

We found that mast cells were present in pubertal mammary glands, and hypothesized that they participate in mammary morphogenesis and are sensitive to IGF1, which is essential for mammary development.As independently reported in another model of mast cell deficiency (Developmental Biology 2010 337 124), mast cell-deficient W/Wv mice had significantly less terminal end buds and ducts and smaller gland areas than controls at 3, 6, ...

Context: Recombinant human GH treatment and oocyte donation (OD) have improved the quality of life in women with Turner syndrome (TS). However, life expectancy is reduced, mainly due to cardiovascular complications. Pregnancy may itself increase that risk and be associated with hazardous materno-fetal outcome.Objective: The objective of this study was to evaluate the materno-fetal outcome of ongoing pregnancies beyond 20 weeks of gestation obtained by OD...