Endocrine Abstracts

Objectives: Subclinical hypothyroidism (SH) is characterized by normal serum free T4 (FT4), free T3 (FT3) levels and increased serum TSH levels. Endothelial dysfunction that is accepted an early step of the atherosclerosis, has been reported in patients with subclinical hypothyroidism. The aim of this study was to eveluate endothelial functions and the effect of L-thyroxine (L-T4) therapy on e...

Glycoregulation disorders in endocrine are frequently, hormone excess or deficit resulting for impaired metabolism of glucose by different mechanisms.Methods: The study was conducted on 118 patients with hyperthyroidism, acromegaly and hypercortisolism. The inclusion criteria were: patients nondiagnostics that have not followed the treatment with drugs that could induce hyperglycemia (epinephrine, oral contraceptives, glucocorticoids, mineralcorticoids e...

Early sexualisation defines the appearance of any sign of sexual maturation at a younger age than 2 S.D. from the mean, namely <8 years at girls and 9 years at boys. The really precocious puberty is always isosexual, sexuality program runs in line with genetic sex and gonads of the subject. In making her part of the whole system gonadal function: the hypothalamus–pituitary–gonad-receptors, and gonads is fully enabled not only hormonogenetic, both a...

Nicotine (N) is known as the main toxic and addictive component of cigarette smoke. By its ability to generate reactive oxygen species (ROS) and oxidative damage in organism, it can induce major public health problems such as cancer, cardiovascular diseases and infertility. Green tea extract (GTE) is an important source of polyphenols catechins; it has attracted a great deal of attention around the world because of its potential antioxidants role in scavenging free radicals. T...

Introduction: Studies suggest that schizophrenia and prolactin raising antipsychotics, one of them being risperidone, may be associated with low bone mass. On the other hand, weight gain as a consequence of antipsychotics in these patients may be the protective factor against osteoporosis.Objective: Determine bone remodeling parameters and bone mass in patients with schizophrenia treated with long-acting injectable risperidone (LAIR) under naturalistic c...

Non-alcoholic fatty liver disease (NAFLD), currently considered a major problem of public health, includes fatty liver alone, steatohepatitis, fibrosis, cirrhosis. Obesity increases the risk of NAFLD in the patients having BMI >30 kg/m2, where the liver involvement is a common aspect.Aim: To find non-invasive methods fro the selection of patients with risk of progression of liver disease.Materials and methods: We sel...

Ovariectomized (OVX) rats are commonly used for the investigation of estrogenic compounds in vivo. We previously showed that estrogen treated OVX animals apparently respond differently to Genistein (GEN) treatment than hormonally intact animals. An observation, that indicated that progestins might interfere in the estradiol (E2)–GEN interaction.As the molecular effects of GEN seem to be modified by progesterone (P4), its...

Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin. Procalcitonin is synthesized by a large number of tissues and organs in response to invasion by pathogenic bacteria, fungi and some parasites. Its a new and innovative parameter which reacts with high sensitivity and specificity to generalized infection and sepsis.Objective: The aim of the study was to assess PCT value for the diagnosis of systemic infection.Meth...

Introduction: To evaluate the efficacy of 3 different parathyroid adenoma screening tools (high resolution ultrasonography (USG), technetium Tc 99m-methoxyisobutylisonitrile (MIBI) parathyroid scintigraphy and magnetic resonance imaging (MR)) and to determine factors affecting the detection success rates.Methods: Thirty-nine patients (29 female and 10 male) with primary hyperparathyroidism were included in the study. Patient’s mean age was 53.9&#177...

Introduction: Glucosinolates (GLS) are secondary plant metabolites found in members of families within the order Brassicales (e.g. broccoli, pak choi, cauliflower, kale, mustard or rapeseed), but they are also present in plants of Moringaceae (moringa) and Caricaceae (papaya). Some GLS-derived breakdown products, i.e. sulforaphane, were extensively studied for their beneficial effects on colon-cancer incidence. This preventive nutritional approach might require the prophylacti...

Phytoestrogen genistein is one of the endocrine disrupting chemicals found mostly in soybean. It has become a topic of interest since decades ago in view of its benefits in reducing the risks of breast cancer, cardiovascular disease, obesity and perimenopausal symptoms. However, it has been reported that genistein can cause adverse consequences on female reproductive system and may cause infertility. Its action was said to be associated with its binding affinity to oestrogen r...