Endocrine Abstracts (2011) 26 P205

LHRH-antagonist cetrorelix may reduce postmenopausal flushing

P M van Gastel, M van der Zanden, D Telting, M Filius, L Bansci & H de Boer

Rijnstate Hospital, Arnhem, The Netherlands.

Background: Estrogen replacement therapy is the most effective treatment for postmenopausal (PMP) flushing, but its use is often contraindicated. An effective and safe alternative is urgently needed.

Aim: To explore the effects of the LHRH receptor antagonist cetrorelix in women with severe PMP flushing who have a mean daily flush score >15.

Methods: Open-label treatment with cetrorelix 250 μg twice a day in nine women with severe PMP flushing, for a period of 4–6 weeks. The response to treatment was evaluated by monitoring serum gonadotropin levels, flush scores, and quality of life.

Results: At baseline, the mean daily flush score was 35.9±2.0 (range 29–44). All subjects demonstrated a decrease in serum LH and FSH during treatment, but premenopausal levels of both gonadotropins were reached in only two subjects. The mean daily flush score decreased by 39.6±8.4% (P<0.005).

Conclusion: Severe PMP flushing can be reduced by LHRH receptor blockade. The data suggest that a longer treatment period is required to capture the maximal effect.

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