Endocrine Abstracts (2011) 26 P528

Diabetes mellitus and the incidence of fracture

A A Gusova, M G Pavlova, G A Melnichenko, G M Kavalersky, L L Silin & N V Zaitseva

I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.

Objective: To study if people with diabetes mellitus (DM) have increased risk of fracture.

Methods: The study population consisted of 29 512 people aged 50 years or more. There were 1981 diabetic patients among them. The records of the local trauma clinic for two-year period were analyzed.

Results: Women with DM had fewer fractures during two years than women without DM (relative risk 0.43; 95% confidence interval 0.30–0.61). The frequency of fractures in men was similar for those with and without DM (RR 0.97; 95% CI 0.59–1.60). We haven’t also found an increased risk of hip fracture (RR 0.7, 95% CI 0.31–1.61) in diabetic people compared with non-diabetic population. However, the incidence of multiply or repeated fractures was significantly higher in diabetic population (1.5‰ vs 0.3‰ in non-diabetic one), it resulted in 5-fold higher risk of these fractures for DM (95% CI 1.94–12.89).

Conclusion: Our data indicate that patients with diabetes don’t have an increased total fracture risk. DM in women is associated with a lower frequency of fracture, which could be explained by low physical activity of these patients. Nevertheless, the increase of multiply/repeated fracture risk indicates poor quality and/or higher risk of traumatic falling in diabetic population.

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