Introduction: The quantitative ultrasound (QUS) is an useful tool in the evaluation of the fragility fracture risk.
Aim and study design: We performed the QUS fragility fracture risk groups (valided by the golden standard DXA) by a unifactorial analyze including the bone markers.
Method: The cut offs used were: SI≤59U (high risk), SI≥83U (low risk), and medium risk with SI between 59 and 83U. The QUS analyze was performed by a heel GE Achilles Device. The statistical analyze used student t test. We studied 130 postmenopausal women who were not treated for osteoporosis.
Results: In a prospective study, the anamnesis, serum bone markers, DXA and QUS were performed. Low risk patients (n=48) and high risk (n=19), without age difference.
31.57% of the patients from the high risk group were diagnosed with osteoporosis, versus 7.6% in the low risk category. The percent of the women with normal DXA was 21.05 vs 56.41%. The percent of the false positive patients (high risk at QUS and normal DXA) was 21.05%. The percent of the false negative patients with osteoporosis was 7.6%. In the high risk group, serum PTH, 25OH-D, osteocalcin, alkaline phosphatase were not significantly different from the group with low risk. In the high risk group, the BMI, total calcium, and Beta Cross Laps were statistically significant different from the low risk group. The percent of the patients with an already known fragility fracture was: 12.5% in the low risk group, versus 26.32% in the high risk group.
Conclusion: Bone markers as PTH, 25 OH D have no influence. The DXA assessment proved significant difference: the osteoporosis was almost 4 times more frequent in the high risk groups while the normal DXA was found two times more frequent in low risk patients (QUS) versus high risk patients.
30 Apr - 04 May 2011
European Society of Endocrinology