Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 26 P120

ECE2011 Poster Presentations Female reproduction (39 abstracts)

Smoking is associated with increased adrenal responsiveness, decreased prolactin levels and a more adverse lipid profile in 650 Caucasian patients with polycystic ovary syndrome

D Glintborg 1 , H Mumm 1 , D M Hougaard 3 , P Ravn 2 & M Andersen 1


1Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark; 2Department of Gynecology and Obstetrics, Odense University Hospital, Odense C, Denmark; 3Section for Neonatal Screening and Hormones, Department of Clinical Biochemistry and Immunology, Copenhagen S, Denmark.


Objective: Smoking may be associated with changes in metabolic risk factors and sex hormones in PCOS.

Design: Retrospective trans-sectional study.

Patients: Six hundred and fifty caucasian premenopausal women with the diagnoses hirsutism or PCOS were divided according to smoking status: Non-smokers (NS-PCOS=390) and smokers (S-PCOS=260). 119 healthy women were studied as controls (NS-Control=105, S-Control=14).

Interventions: Clinical evaluation, hormone analyses, transvaginal ultrasound. Oral glucose tolerance tests (OGTT) and ACTH tests.

Main outcome measures: Clinical, metabolic, and endocrine parameters. ACTH stimulated cortisol and 17-hydroxyprogesterone (17OHP) levels.

Results: S-PCOS has significantly higher fasting lipid profile and 17OHP levels (basal and ACTH stimulated) than NS-PCOS patients, whereas prolactin levels were decreased. No significant differences were found in body composition and measures of insulin resistance between NS-PCOS and S-PCOS. PCO was more prevalent in NS-PCOS patients. During multiple regression analyses, smoking was positively associated with 17OHP and cholesterol, triglycerides, and low density lipoprotein and inversely associated with prolactin and high density lipoprotein.

Conclusion: Smoking was associated with increased adrenal responsiveness, decreased prolactin levels and a more adverse lipid profile in PCOS patients, whereas smoking was unassociated with body composition and insulin resistance. Smoking may be associated with the prevalence of individual Rotterdam criteria.

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