Endocrine Abstracts (2011) 26 P296

Primary pituitary tumors: 10-year single center experience

A Gkountouvas, I Kostoglou-Athanassiou, M Nikas, F Chatzimarkou, I Keramidas, D Thomas, P Georgiadis & P Kaldrymidis


Department of Endocrinology, Metaxa Hospital, Pireaus, Greece.


Primary pituitary tumors are relatively rare and mainly benign.

The aim was to study the primary pituitary tumors presenting during a 10-year period in a single center.

The archives of all patients with primary pituitary tumors having been hospitalized from 01.01.2000 to 30.06.2010 in the Department of Endocrinology and Metabolism of Metaxa Hospital were studied. Within this cohort of patients 128 were female (63%) and 75 (37%) were male (ratio 1:1.7). All patients had benign neoplasms. The majority of the patients had acromegaly (78 patients, 38%) and non secreting pituitary adenomas (58 patients, 28%). Patients with prolactinoma represented 17% (35 patients), while patients with Cushing’s disease 11% (23 patients). In 1 patient (<1%) a TSH secreting adenoma was diagnosed. Multiple hormone secreting adenomas had 4 patients (2%). Within this cohort 3 patients (<2%) had adenomas secreting GH and prolactin and 1 had an adenoma secreting GH and TSH. In 3 (<2%) patients cysts were found in the pituitary and in 1 of them it proved to be Rathke’s cyst. Finally, in 1 patient (<1%) a craniopharyngioma was diagnosed.

In conclusion, primary pituitary tumors are rare and mainly benign. In our cohort prolactinomas appear not to be as many as expected, as currently patients with prolactinoma are treated mainly as outpatients.

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