Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 26 P326

ECE2011 Poster Presentations Obesity (47 abstracts)

Serum leptin level and its association with body composition in obese children

M Vishnevskaya & A Solnceva


Belarusian State Medical University, Minsk, Belarus.


Body composition using dual energy X-ray absorptiometry (DEXA) can be used as an specific method for measuring fat mass and identify individual risk for cardiovascular and metabolic complications in obese children.

Objective: To investigate serum leptin level and its relationship with fat distribution in obese children.

Materials and methods: Eighty-seven children (male/female=43/44, mean age 12.81±0.5 years). obese (BMI>95 percentile for age and sex). DEXA was used to body composition. Serum leptin level was measured using ELISA. Analysis was performed non-parametric (ANOVA, test of Mann–Whitney U) and parametric (t-Student criterion) methods (P<0.05).

Results: BMI in a group of girls 28.3±0.52 kg/m2, a group of boys 29.7±0.68 kg/m2 (P=0.05). DEXA data (m/f): Gynoid (%) – 51.05±0.93/53.98±0.58 (P>0.05), Android (%) – 46.93±0.68/51.29±0.52 (P=0.05), A/G – 1.09±0.02/1.05±0.01 (P>0.05), total body – 42.5±0.71/46.65±0.54 (P=0.05), fat – 39.55±2.3/34.2±1.4 kg (P=0.01), free fat – 50.5±2.4/41.3±1.5 kg (P=0.05), arms+legs/trunk – 0.99±0.03/0.93±0.03 (P>0.05), legs/total – 0.38±0.01/0.37±0.01 (P>0.05), trunk/total – 0.49±0.01/0.51±0.01 (P>0.01), lean mass – 47.8±2.4/38.8±1.5 kg (P=0.05).

Serum leptin level was positively correlated with body composition indicators: boys group: free fat (r=0.48–0.85, P<0.01), lean mass (r=0.52–0.69, P<0.01), Gynoid (%) (r=0.5–0.74 P<0.01), Android (%) (r=0.65–0.85 P<0.05), girls group: free fat (r=0.69–0.85, P<0.01), lean mass (r=0.4–0.52, P<0.01), Gynoid (%) (r=0.64–0.85 P<0.05), Android (%) (r=0.65–0.78 P<0.01). Correlation between OT/ON to the A/G (m/f – r=0,56/0,6) without gender differences were established.

Conclusion: Gender differences in body composition were revealed in obese children. Serum leptin concentration is significantly correlated with body composition.

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