Introduction: Obesity caused health problems are increasing. Metabolic syndrome including obesity with insulin resistance, hypertension, and high blood lipid levels increases the risks of cardiovascular and inflammatory diseases. Many studies have reported that heme oxygenase (HO) inducers reduce insulin resistance and severity of inflammatory bowel disease. We investigate the anti-inflammatory effect, one among many positive effects, of regular recreational physical activity in rat colitis model provoked by trinitrobenzene sulphonic acid (TNBS).
Methods: After 6 weeks self-administered physical activity (running wheel) male Wistar rats were treated with TNBS (10 mg). 72 h after TNBS challenge we measured colonic inflammatory parameters and HO activity.
Results: The colonic inflammatory damage were significantly decreased by physical activity (extent of lesion: from 49.7±0.9 to 38.4±4.4%; severity of mucosal damage: from 7.3±0.1 to 6.1±0.4; n=1012, P<0.05). The regular physical activity enhanced HO activity in the running control group compared to the sedentary control group (from 1.06±0.16 to 5.48±0.29 nmol bilirubin/h per mg protein; n=1012, P<0.001). The TNBS treatment increased the HO activity both in the non-running sedentary control and running groups.
Conclusion: Long lasting recreational physical activity improves bodys defense mechanisms. Physical activity-induced increasing activation of HO system may play role of these mechanisms including colonic inflammation.
This work is supported by the SROP 4.2.1./B-09-1/KNOV-210-0005 and SROP 4.2.2.-08/1-2008-0006 research grants.
Rotterdam, The Netherlands
30 Apr - 04 May 2011
European Society of Endocrinology