Endocrine Abstracts (2011) 26 P446

Vitamin D levels are associated with serum TSH levels but not with thyroid autoantibodies

Mehmet Colbay, Mustafa Altay, Mujde Akturk, Nuri Cakir, Ilhan Yetkin & Metin Arslan


Endocrinology and Metabolism Department, Gazi University Hospital, Ankara, Turkey.


Introduction: Hashimoto’s thyroiditis (HT) is common autoimmune thyroid disorder and is predominantly the clinical expression of cell-mediated immunity leading to destruction of thyroid cells. Vitamin D plays a role in the regulation of immunity and cell proliferation. So, do the serum levels of vitamin D reduced in HT?

Methods: We examined the medical records of the ‘Thyroid policlinic’ patients with or without HT. Vitamin D, thyroid autoantibodies and TSH levels that evaluated in winter month’s interval (January–March 2010), were assessed.

Results: Totally, 319 patients (196 with HT, 123 without HT and 25 male) medical records were reviewed. Their demographic and clinical characteristics were shown in Table 1. There were no differences between ages, vitamin D and TSH levels except for the autoantibodies. But there was a significant negative correlation between the vitamin D levels and TSH levels (P<0.001).

Conclusion: The serum levels of vitamin D were not reduced in patients with HT. Levels of vitamin D are associated with serum TSH levels (negatively) but not with thyroid autoantibodies.

Table 1 Demographic and clinical characteristics.
ParametersPatients with HTPatients without HTP
Age44.8±11.243.6±12.9NS
Vitamin D (ng/ml)14.9±9.914.9±11.6NS
Anti-TG (U/ml)814.9±190934.3±10.90.001
Anti-TPO (U/ml)897.1±2150.238.0±11.70.001
TSH (μIU/ml)2.78±3.23.07±7.9NS

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