Endocrine Abstracts (2011) 26 P483

Malignancy rate is not different in dominant nodule and non- dominant nodule by fine needle thyroid aspiration

Omer Yazgan1, Fahri Halid Besir1, Yusuf Aydin2, Sibel Yazgan1, Melih Engin Erkan3, Burhan Yazici1, Ramazan Büyükkaya1 & Omer Onbas1


1Faculty of Medicine, Radiodiagnostic Department, Düzce University, Duzce, Turkey; 2Faculty of Medicine, Endocrinology and Metabolism Department, Duzce University, Duzce, Turkey, 3Faculty of Medicine, Nuclear Medicine Department, Duzce University, Duzce, Turkey.


Objective: Thyroid fine-needle aspiration biopsy (FNAB) is the golden standard for approaching thyroid nodule’s malignancy. It is recommended to carry out an FNAB from the dominant nodule in multi nodular goiter. In our study, we compared the FNAB results that we carried out from dominant nodule and any other nodule which have features that may be malignant to US. Besides, the relationship between the results of cytology and US features of nodules has been analyzed.

Material and methods: One hundred and ninety-seven cases diagnosed MNG were analyzed between 2009–2010, These cases followed by applying to endocrinology polyclinic were carried out FNAB from both dominant nodule and non-dominant nodule. Whole cystic nodules, nodules with peripheral calcification and nodules that its FNAB result has poor material were not used in the study and 171 cases were used. As a malignancy criterion at US, including hypo echoic pattern, solid structure, micro calcification features of nodule and not having peripheral halo feature of nodule were used. In statistical analyze, P<0.05 was accepted as significant.

Results: While malignancy rate was found 1.8% in dominant nodules, in non-dominant nodules malignancy rate was found 0.6% (total malignancy rate: 2.4%) and statistically it was not observed significant difference (P=0.53). In the cytological analyze of non-dominant nodules, malignancy rate was found significantly high (P<0.001) which those including micro calcification. In nodules not having peripheral halo, malignancy rate was also found significantly high (P=0.048). It was not determined statistically significant relation between malignancy and, hypo echoic pattern, solid structure as US features of nodules.

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