Endocrine Abstracts (2011) 26 P499

Osteoporosis in the women with metabolic syndrome

Lali Kilasonia, Nino Rusia, Luba Lagvilava & Tamara Burchuladze

‘Medulla’clinic, Tbilisi, Georgia.

Background: It is recognized worldwide that the endocrine diseases lead among the causes of secondary osteoporosis. Based on many studies there was established the frequency of osteoporosis during the thyroid disorders, diabetes mellitus, hypercorticism. The most obscure in this line is the metabolic syndrome. The study of bone mineral density index during the metabolic syndrome is interesting from the aspect that until now the obesity has been considered to be the prevention of osteoporosis…

Objectives: The objective of the work was to study the bone mineral density in women with metabolic syndrome, detection of correlations between the bone metabolism and those criteria which accompany the metabolic syndrome.

Methods and materials: Ninety women with metabolic syndrome (MS) were studied, aged 25–50 (the average age 30.5–40.7). The diagnosis included the body mass index (BMI), fat distribution variants, obesity accompanying complications. All patients underwent the oral glucose meal, fasting blood sugar test, fasting immunoreactive insulin test and glucose loading insulin test. The patients were divided into 3 groups: 1st Group – 34 women with full MS diagnosis (30.7%), 2.27 aptients with MS diagnosis without carbohydrate metabolism disorder (39%). 3.29 patients with MS diagnosis without dislipidemy. All patients underwent the densitometric study by the dual energy X-ray absorption densitometers (Hologic Q-1000); the bone mineral density was measured in lumbar vertebrae, in the femoral neck, distal forearm area, using Tscore criterion.

Results: The results of the study appeared to be interesting not only for determination of the osteoporosis frequency during MS but for establishment of rhetoric relations between obesity and bone mineral density; out of 90 patients in 31 cases the low bone mineral density (T≤−2.5) was fixed mainly (35%) in the femoral neck – 11 patients, Ward’s triangle – 10 patients and in the distal forearm area – 20 patients. The osteopenic syndrome (T≤−2.0) was revealed in 11 patients mainly in those skeleton fragments which are represented with the cortical bones. From the aspect of patient’s age the frequency of low bone density index was very surprising.

Conclusion: The more frequent low bone mineral density was revealed during MS with hyperinsulinemia. No correlation between the BMD index and dislipidemia quality was revealed. Obesity does not exclude the osteoporosis during MS and correlated with the gravity of syndrome.

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