Endocrine Abstracts (2011) 26 P523

Vitamin D and bone metabolism in adult patients with cystic fibrosis

L Vuolo1, V Carnovale2, E Guerra1, M Rubino1, P Contaldi1, F Rengo2, A Colao1 & C Di Somma1

1Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica Università Federico II, Napoli, Italy; 2Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche Università Federico II, Napoli, Italy.

Objective: To evaluate Vitamin D levels and bone metabolism in adult patients with cystic fibrosis (CF).

Patients and methods: One hundred patients with CF (53 F, 47 M; age 29±8 years). and 100 healthy controls were enrolled. Patients were assessed through clinical, and laboratory investigations. Evaluation of serum 25 hydroxy vitamin D (25OHD), vertebral fractures (quantitative morphometric analysis) and bone mineral density (BMD) at lumbar spine and total hip (dual energy X-ray absorptiometry) was done.

Results: Serum 25 OHD vitamin D was lower in patients than in controls (P<0.001). Vitamin D deficiency (<10 ng/ml) was observed in 14%, vitamin D insufficiency (10–30 ng/ml) in 47% and normal value of vitamin D (30–100 ng/ml) in 39% of CF patients. Osteoporosis was found in 15%, while osteopenia in 28% of CF patients. Normal values of BMD was found in 57% of them. Furthermore, in 10 patients we evaluated vertebral fractures: the fractures were mild in two patients (20%), moderate in five (50%), and severe in two patients (20%). 25OHD vitamin D levels was not related to T and Z score at lumbar spine and femoral neck (P=0.431; P=0.487; P=0.629; P=0.849, respectively).

Conclusions: This study reports a high prevalence of vitamin D deficit and osteoporotic vertebral fractures in adult patients with CF, suggesting that complicated osteoporosis is an important comorbidity of CF patients. Adequate supplementation with vitamin D and treatment for osteoporosis could improve the quality of life of these patients.

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