Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 26 P561

ECE2011 Poster Presentations Cardiovascular endocrinology and lipid metabolism (34 abstracts)

Young women with the polycystic ovary syndrome (PCOS) have evidence of endothelial dysfunction but not of altered arterial structure

I Duncea 1 , I R Ilie 1 , C Georgescu 1 , I Marian 2 , T Mocan 3 , B Man 1 , C Brad 1 & G Hazi 4


1Department of Endocrinology, University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Department of Internal Medicine-Cardiology, University of Medicine and Pharmacy, Cluj-Napoca, Romania; 3Department of Physiology, University of Medicine and Pharmacy, Cluj-Napoca, Romania; 4Clinical Laboratory, Emergency County Hospital Cluj, Cluj-Napoca, Romania.


Aim: The aim of our study was to assess the presence of endothelial dysfunction and of increased carotid intimae-media thickness (IMT), two precocious markers of atherosclerosis in PCOS subjects. Simultaneously, their relationship with some metabolic, hormonal and anthropometric parameters was analyzed.

Methods: The study group consisted of 45 women with PCOS (age=23.1±4.1 years, body mass index (BMI) =28.4±5.9 kg/m2). Thirty-two healthy age-matched women (23.0±5.3 years and BMI=25.8±6.8 kg/m2) were included as controls. All women were evaluated clinically and biochemically. Serum insulin, total testosterone, sex hormone binding globulin and estradiol were measured using ELISA commercial kits. Intimae-media thickness was assessed by high-resolution ultrasonography at the level of common carotid artery bilaterally, while endothelial dysfunction was investigated by both endothelin (ET)-1 levels determination and measurement of flow-mediated dilatation (FMD) of the brachial artery.

Results: ET-1 levels were significantly higher while the FMD was significantly lower in the PCOS women compared with the control women (P=0.001). In contrast, no difference was observed between the two groups in carotid artery IMT. In the total study group, both ET-1 (correlation with TT: r=0.439, P<0.0001 and with the free androgenic index (FAI): r=0.448, P<0.0001) and brachial artery FMD (correlation with the FAI: r=−0.242, P=0.046) were significantly associated with hyperandrogenemia markers. In multiple regression analyses for the total population, only PCOS presence represented an independent predictor of FMD levels (b=−0.406, P=0.001).

Conclusions: Our data show that young, non-dyslipidemic, non-hypertensive and eu-glycaemic women with PCOS have altered endothelial function but not evidence of altered arterial structure and that increased androgen levels are linked to impaired endothelial function.

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