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15th International & 14th European Congress of Endocrinology

ea0029jp1 | (1) | ICEECE2012

Melanocortin receptor accessory proteins (MRAPs) in adrenal gland physiology and beyond

Chan LF

The melanocortin receptor (MCR) family consists of five G protein-coupled receptors (MC1R-MC5R) with diverse physiological roles. MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, whilst MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.The melanocortin receptor accessory proteins, MRAP and its paralogue MRAP2, are small single-pass transmembrane proteins tha...