Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2012) 29 P908

ICEECE2012 Poster Presentations Female Reproduction (99 abstracts)

Prevalence of elevated glycated hemoglobin in women with polycystic ovary syndrome: according to the recently defined criteria

S. Chae 1 , J. Kim 2, , Y. Choi 2 , K. Hwang 2, , S. Yoon 5 & K. Kim 2,

1Maria Fertility Hospital, Seoul, Republic of Korea; 2Seoul National University College of Medicine, Seoul, Republic of Korea; 3Seoul National University Hospital, Seoul, Republic of Korea; 4Seoul National University Borame Medical Center, Seoul, Republic of Korea; 5Dongguk University Ilsan Hospital, Goyang, Republic of Korea.

Background: Insulin resistance is a core pathophysiology of polycystic ovary syndrome (PCOS). The screening recommendations for type 2 diabetes in PCOS patients have varied according to organizations, but the AE-PCOS Society recommended that a OGTT be performed in obese patients or in lean patients with advanced age (>40 year), with a history of gestational diabetes, or with a family history of type 2 diabetes. Recently, the American Diabetes Association (ADA) newly includes hemoglobin A1c (A1C) as a component of diagnostic criteria of ‘diabetes’ (≥6.5%) or ‘increased risk for diabetes’ (5.7–6.4%). This study was performed to examine the prevalence and the risk factors for elevated A1C (≥5.7%) in women with PCOS compared to age matched control women.

Methods: A1C was evaluated in 154 patients and 469 controls.

Results: One-third (31.2%) of the PCOS patients had elevated A1C. The prevalence of elevated A1C was similar in obese PCOS and obese controls (23.5 and 20.0%, respectively, P=1.0), but non-obese PCOS women (mean age 29.8±5.4 years) had a higher prevalence of elevated A1C than non-obese controls (31.2 vs 6.6%, respectively, P<0.001). The prevalence of elevated fasting plasma glucose was not different. The odds that a woman has an elevated A1C was 6.7 times higher if she has PCOS (adjusted OR 6.67, 95% CI 3.50–12.70).

Conclusions: Non-obese PCOS patients presented a significantly higher prevalence of elevated A1C than non-obese controls, whereas in obese subjects, the prevalence of elevated A1C was similarly elevated. Since substantial proportion of young and non-obese PCOS women are at an increased risk for diabetes, screening for type 2 diabetes may be necessary even in these young and non-obese PCOS patients. Future studies is mandatory to assess whether A1C is as effective as OGTT as a diagnostic tool in patients with PCOS.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This work was supported, however funding details unavailable.

Volume 29

15th International & 14th European Congress of Endocrinology

European Society of Endocrinology 

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