Searchable abstracts of presentations at key conferences in endocrinology
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15th International & 14th European Congress of Endocrinology

Oral Communications

Cardiovascular Endocrinology

ea0029oc19.1 | Cardiovascular Endocrinology | ICEECE2012

Both EPA/AA ratio and absolute AA levels constitute an independent risk factor for coronary atherosclerosis in type 2 diabetic patients

Nakamua T. , Maegawa H.

Background: N-3 polyunsaturated fatty acids (PUFA), such as α linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to modify several key risk factors for cardiovascular disease, although n-6 PUFA arachidonic acid (AA) has important roles in inflammation. However, it is not clear whether the apparent protection of n-3 PUFA against cardiovascular disease has been found in diabetic patients.Methods: To clari...

ea0029oc19.2 | Cardiovascular Endocrinology | ICEECE2012

Increased arterial stiffness is independently associated with cerebral infarctions and white matter lesions in patients with type 2 diabetes despite good blood pressure and lipid control

Laugesen E. , Hoyem P. , Gron B. , Mikkelsen A. , Kim W. , Thrysoe S. , Erlandsen M. , Christiansen J. , Knudsen S. , Hansen K. , Hansen T. , Poulsen P.

Aim: Patients with type 2 diabetes (T2DM) have increased risk of cardiovascular disease (CVD) including stroke. The risk of CVD is traditionally assessed using office blood pressure (BP) and lipid profile. Increased arterial stiffness predicts cardiovascular events in the general population. We investigated if arterial stiffness was associated with cerebrovascular disease in patients with T2DM and sex- and age-matched controls indepentl y of classical risk factors.<p class...

ea0029oc19.3 | Cardiovascular Endocrinology | ICEECE2012

Copeptin and adrenomedullin in a large cohort of patients with coronary heart disease and newly diagnosed glucose intolerance (‘Silent diabetes study’)

Kusche S. , Doerr R. , Hartmann O. , Morgenthaler N. , Schnell O. , Lohmann T.

Background: Copeptin is used as a diagnostic marker for acute myocardial infarction, adrenomedullin as a prognostic marker for congestive heart failure. Both hormones may be involved in pathophysiology of metabolic syndrome.Methods: We have used sera of the ‘Silent diabetes study’ (1). Sera of 920 patients were eligible for this analysis. All patients underwent an oral glucose tolerance test, patients with previously known diabetes were exclude...

ea0029oc19.4 | Cardiovascular Endocrinology | ICEECE2012

Oxytocin is cardioprotective hormone

Gutkowska J. , Jankowski M.

We have uncovered the entire functional oxytocin (OT) system in the rat and human heart. In the experimentally-induced myocardial infarction (MI) in rats, the continuous OT delivery improves the cardiac work, reduces inflammation, and stimulates angiogenesis. We hypothesized that these actions of OT are mediated by increase in glucose uptake in cardiomyocytes (CM). Indeed OT (10 nM) increased basal glucose uptake in CM to 4.0±0.2 fmol/mg protein in comparison to 2.2 fmol/...

ea0029oc19.5 | Cardiovascular Endocrinology | ICEECE2012

Circulating adrenomedulin levels are associated with atrial natriuretic peptide and brain natriuretic peptide levels in heart failure patients

Holmager P. , Schou M. , Egstrup M. , Gustafsson I. , Goetze J. , Gustafsson F. , Hildebrandt P. , Faber J. , Kistorp C.

Introduction: Heart failure is characterised by an up-regulation of neurohoromones, and brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) are well-established diagnostic biomarkers with substancial prognostic value. Adrenomedullin is a vasoactive peptide and a potential biomarker of vascular injury in patients with cardiovascular disease (CVD) The aims of the present study were to investigate whether mid-regional pro adrenomedullin (MR-proADM) is predictive ...

ea0029oc19.6 | Cardiovascular Endocrinology | ICEECE2012

Endothelial progenitor cells in acromegaly are reduced and responsive to treatment with somatostatin analogues

Albano I. , Fadini G. , Dassie F. , Martini C. , Agostini C. , Avogaro A. , Sicolo N. , Vettor R. , Maffei P.

Introduction: Acromegaly is characterized by high cardiovascular morbidity and mortality possibly due to increased prevalence of main traditional cardiovascular risk factors. It is not clear though whether the incidence of atherosclerosis is truly enhanced. Moreover recent in vitro studies show a protective role of (GH) and IGF1 (insulin-like growth factor-1) on the endothelium. As expression of endothelial regenerative reserve, endothelial progenitor cells (EPCs) could...