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15th International & 14th European Congress of Endocrinology

Poster Presentations

Steroid metabolism + action

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Thyroid (non-cancer)

ea0029p1543 | Steroid metabolism + action | ICEECE2012

Anti-inflammatory effect of a high dose of corticosteroids is associated with some paradoxical pro-inflammatory effects

Dandona P. , Ghanim H. , Abuaysheh S. , Dhindsa S. , Green K. , Frachetti K.

We have previously demonstrated that a low dose of hydrocortisone (100 mg) given intravenously suppresses intranuclear NFκB and AP-1 binding and the expression of pro-inflammatory genes like MMPs. We have now investigated the effect of a high dose of hydrocortisone (300 mg=60 mg prednisolone) on NFκB binding and the expression of TLRs, the mediators of TLR signal transduction, MyD88 and TRIF and HMG-B1. Ten normal subjects were injected intravenously with 300 mg of h...
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ea0029p1544 | Steroid metabolism + action | ICEECE2012

Acute and chronic effects of low dose prednisolone on carbohydrate metabolism in subjects with inflammatory rheumatologic disease

Petersons C. , Mangelsdorf B. , Jenkins A. , Greenfield J. , Thompson C. , Burt M.

High dose glucocorticoids reduce hepatic and peripheral insulin sensitivity and insulin secretion. However, the metabolic consequences of typical therapeutic glucocorticoid doses (e.g. prednisolone <10 mg/day) are poorly characterised. The aim was to determine the acute effect of low dose prednisolone on carbohydrate metabolism and then assess whether subjects taking chronic prednisolone had increased adiposity that amplified carbohydrate metabolism perturbations.<p cl...
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ea0029p1545 | Steroid metabolism + action | ICEECE2012

The influence of aromatizable and non-aromatizable steroids on anthropometric parameters

Pospisilova H. , Duskova M. , Hill M. , Meloun M. , Bendlova B. , Vankova M. , Starka L.

Objective: It is known sex steroids affect fat distribution with men and women. With men there is a tendency to deposit fat abdominally. Men are more likely to have more visceral fat than premenopausal women, with whom the preferential fat distribution is gluteofemoral and the percentage of body fat overall higher. Androgens may affect fat tissue with men either directly by androgen receptor stimulation, or indirectly by oestrogen receptor stimulation after aromatization. Inte...
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ea0029p1546 | Steroid metabolism + action | ICEECE2012

Effect of smoking cessation on hormonal balance

Hruskovicova H. , Duskova M. , Simunkova K. , Pospisilova H. , Hill M. , Vondra K. , Starka L.

Introduction: Cigarette smoking is one of the most serious substance abuse problems. It is generally accepted that nicotine and other chemicals in tobacco smoke alter endocrine functions in men and adverse reproductive outcomes, including deterioration of sperm. Studies on the effects of smoking and smoking cessation on male sex hormones are inconsistent. We studied changes of hormonal levels in men during smoking cessation and we looked for a possible predictive marker of suc...
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ea0029p1547 | Steroid metabolism + action | ICEECE2012

Conversion of 7α-hydroxyDHEA into 7-ketoDHEA: Role of type 2 11β-hydroxysteroid dehydrogenase

Ngo-Duy C. , Labrie F. , Luu-The V.

It has been suggested that DHEA metabolites, especially 7-hydroxy and/or 7-keto derivatives could possess anti-inflammatory activity and enhance immune, cognitive and metabolic functions in rodents. It is thus important to elucidate the exact pathway (s) leading to the formation of these metabolites. While the role of cytochrome P450 CYP7B1 in the transformation of DHEA into 7α-OHDHEA is well recognized, the role of type 1 11β-hydroxysteroid dehydrogenase (11β-H...
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ea0029p1548 | Steroid metabolism + action | ICEECE2012

Steroid derivatives as pure antagonists of the androgen receptor

Gauthier S. , Martel C. , Labrie F.

Introduction: While the androgens of testicular origin (representing about 50% of total androgens in men over 50 years) can be completely eliminated by surgical or medical castration with GnRH (gonadotropin-releasing hormone) agonists or antagonists, the antiandrogens currently available as blockers of androgen binding to the androgen receptor (AR), namely bicalutamide (BICA), flutamide (FLU) and nilutamide have too weak affinity to completely neutralize the 50% of androgens m...
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ea0029p1549 | Steroid metabolism + action | ICEECE2012

The cellular fate of CYP19A1 (aromatase) protein

Pignatti E. , Ferioli S. , Carani C. , Rochira V. , Poti F. , Simoni M.

Introduction: Aromatase cytochrome P450 is uniquely responsible for estrogen synthesis in vertebrates. The protein is expressed in the gonads and other extraglandular tissues. Deregulated expression of aromatase has pathological relevance and targeting the CYP19A1 product could be an effective strategy for treatment of affected tissues. Nevertheless, very little is known concerning the role of protein oligomerisation, glycosylation and degradation. Here we studied the aromatas...
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ea0029p1550 | Steroid metabolism + action | ICEECE2012

Detection of BclI and A3669G polymorphisms in glucocorticoid receptor gene in patients with rheumatoid arthritis

Antic J. , Petakov M. , Roganovic N. , Macut D. , Ognjanovic S. , Djurovic M. , Lakocevic M. , Dragicevic N. , Damjanovic S.

Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease which is characterized with dysregulation of the immune system. Recent studies suggest that dysregulation of the HPA axis may as well play a contributory role in the pathogenesis of RA. Glucocorticoid hormones (GC) accomplish their effects through binding to glucocorticoid receptor (GR). Presence of GR gene polymorphisms can modulate GC effects. The A3669G polymorphism in human GR gene has been connected...
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ea0029p1551 | Steroid metabolism + action | ICEECE2012

Aromatase activity after a short-course of Letrozole administration in adult men at sea level and in men at high altitude (with or without excessive erythrocytosis)

Gonzales G. , Tapia V. , Gasco M. , Gonzales-Castaneda C.

Men living at high altitudes in Peru compared to sea level counterparts have erythrocytosis (Hemoglobin: 16–21 g/dl) or excessive erythrocytosis (Hemoglobin>21 g/dl). High testosterone (T) levels in men at high altitude (HA) were associated with excessive erythrocytosis. High androgen levels could be due to a low aromatase activity or to an elevated rate of conversion from precursors to testosterone. The aim of this study was to evaluate aromatase activity and rate of...
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ea0029p1552 | Steroid metabolism + action | ICEECE2012

Myostatin and Follistatin expression in orchidectomized rats submitted to exercise

Marine D. , Bueno P. , Silva R. , Selistre-Araujo H. , Nonaka K. , Leal A.

Myostatin (MSTN) is a negative regulator of skeletal muscle growth, while androgens are strong positive regulators of muscle growth and strength. Follistatin (FS) is a binding protein which inhibits MSTN action. Evidences suggest that MSTN and testosterone actions in muscle may be associated. However, the mechanisms of androgens actions are not fully elucidated. The objective of this study was to evaluate the influence of exercise training in the expression of MSTN and FS in o...
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ea0029p1553 | Steroid metabolism + action | ICEECE2012

The role of long-acting parenteral testosterone undecanoate compound (Nebid 1000 mg) in the induction of secondary sexual characteristics (SSC) in males with hypogonadotropic hypogonadism (HH)

Giagulli V. , Triggiani V. , Corona G. , Tafaro E. , Licchelli B. , Guastamacchia E.

Testosterone (T) can induce SSC in young HH men. So far the T ester formulations have been used for inducing puberty in these patients. Moreover, it seems that the polymorphism CAG length of androgen receptor (AR-CAG) might co-regulate the effectiveness of testosterone therapy (Tth).This study aims to evaluate the effectiveness of Nebid (1000 mg) for SSC induction in HH men and, secondly, whether these changes might be modulated by the AR-CAG.<p clas...
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ea0029p1554 | Steroid metabolism + action | ICEECE2012

IL-6, Cortisol and early morning stiffness in patients with rheumatoid arthritis: endocrine changes associated with clinical improvement in a chronic autoimmune disease

Jessop D.

Joint stiffness in rheumatoid arthritis (RA) is worse in the morning and has been associated with increased secretion of the pro-inflammatory cytokine IL-6 and in decreased secretion of cortisol, suggesting that clinical symptoms may be related to hormonal and immune circadian variations. We measured 24 h plasma profiles of IL-6 and cortisol in RA patients to determine any changes in IL-6 and cortisol following a two week course of prednisone administered orally in a specially...
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ea0029p1555 | Steroid metabolism + action | ICEECE2012

Abstract withdrawn...
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ea0029p1556 | Steroid metabolism + action | ICEECE2012

Fetal liver may reinstate activity of GABAergic steroids inactivated by placental oxidoreductases

Kanceva R. , Hill M. , Parizek A. , Kancheva L. , Starka L.

Recently we have completed steroid metabolomic study including unconjugated (n=39) and conjugated steroids (n=30) in maternal and fetal body fluids using GC-MS method with two separate multicomponent analyses (for unconjugated steroids and steroid polar conjugates). Our previous data indicate that primarily oxidative isoforms of pluripotent 17β-hydroxysteroid dehydrogenases and aldoketoreductases in placental tissue close to the fetal compartment convert 3&#...
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ea0029p1557 | Steroid metabolism + action | ICEECE2012

Unconjugated steroids and steroid sulfates in maternal blood show comparable predictivity for assessment of gestational age from the 28th to 41st week of pregnancy

Kancheva L. , Hill M. , Kanceva R. , Parizek A. , Starka L.

Recently we demonstrated a close correlation between the gestational age (GA) and steroid metabolome in maternal and fetal body fluids using multivariate models including both unconjugated (n=39) and conjugated steroids (n=30) that were measured by GC-MS method including two separate multicomponent analyses (for unconjugated steroids and steroid polar conjugates). We focused on the comparison of the predictive value of the levels of unconjugated steroids alone, c...
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ea0029p1558 | Steroid metabolism + action | ICEECE2012

Anabolic hormones in acute exacerbation of chronic obstructive pulmonary disease: relation of hypogonadism with indexes of severity and phlogosis

Berardino A. Di Marco , Mancini A. , Inchingolo R. , Raimondo S. , Segni C. Di , Pontecorvi A. , Valente S. , Corbo G.

Nowadays Chronic Obstructive Pulmonary Disease (COPD) is not considered a lung specific disease: nutritional alteration, weight loss due to increased energetic expenditure, loss of muscle mass are systemic effects, correlated with the risk of hospitalization due to exacerbation (AECOPD). AECOPD, characterised by augmented indexes like C reactive protein, interleukin-6, procalcitonin and serum amyloid A (SAA), negatively influenced natural history of the illness and were found ...
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ea0029p1559 | Steroid metabolism + action | ICEECE2012

Long-term evaluation of cross-sex hormone treatment in transsexual persons

Wierckx K. , Weyers S. , Caenegem E Van , Roef G. , Heylens G. , T'Sjoen G.

Objective: To describe the effects and side effects of cross-sex hormone therapy in both transsexual men and women.Design: Single center cross-sectional study in one hundred transsexual persons post SRS and on average 10 years on cross-sex hormone therapy.Methods: Hormone levels were measured by immunoassays. Physical health was assessed by physical examination and questionnaires on general health and specific side effects, areal b...
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ea0029p1560 | Steroid metabolism + action | ICEECE2012

Physiological relevance of peripherally produced gabaergic and glycinergic steroids in human late pregnancy and around parturition

Hill M. , Parizek A.

Although neuroactive steroids are well characterized, their physiological relevance in human pregnancy remains indecisive. Hence, we attempted to derive this information from the combination of our metabolomic data, pharmacological data found in the literature and knowledge contained in gene expression databases. These results indicate that GABAergic steroids influence maternal CNS but have limited effect in the fetal brain and maternal and fetal periphery, partly because of t...
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ea0029p1561 | Steroid metabolism + action | ICEECE2012

Influence of endogenous hormones and testosterone in the prostate cancer

Jimenez-Pacheco A. , Arrabal-Polo M. , Lopez-Torne M. , Suleiman-Martos Y. , Zuluaga-Gomez A. , Escobar-Jimenez F. , Arrabal-Martin M.

Introduction: Androgen stimulation of prostate cancer (PCa) cells has been the basis for extensive studies evaluating the role of androgen in PCa but the diagnostic measurement of androgen as well as androgen values that potentially influence prognosis are unclear in patients with PCa. The aim of this studies is to analyze the hormone behavior in the prostate cancer (PCa), as well as the relationship between PSA-testosterone and testosterone-aggressiveness tumor and compare th...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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