Endocrine Abstracts

GH therapy in children with PWS was approved in the US in 2000, based on short term growth data, and in Europe in 2006, based on growth and body composition data. GH therapy in PWS has been used by the medical community and advocated by parental support groups since this time. The advent of GH therapy for individuals with PWS represents a unique therapeutic challenge with its intersection of GH treatment for individuals with cognitive disability, varied therapeutic goals that ...

Hypopituitarism and impaired fertility in adulthood may result from congenital genetic defects detected during childhood or acquired pituitary dysfunction after apoplexy or resection of a pituitary tumor or following radiation therapy. This lecture will review the fertility options for hypopituitary patients, success rates and predictors of outcome for conception and live births. In those with normal pituitary function planning surgery and/or radiation to the hypothalamic-pitu...

Once induction of puberty has been completed the options for sex steroid hormone replacement change to take in to account long term health outcomes and the issues of transition from pediatric to adult care. With regard to the late stages of development, some thought has to be given to the fact that bone mass continues to increase to reach a peak at about the age of 25. It may not be until the age of 18 that meaningful bone density results can be obtained. For those who are slo...