Endocrine Abstracts

Diabetes is a strong risk factor for cardiovascular (CV) events, and large epidemiologic studies have repeatedly shown that higher fasting or post-load glucose levels predict a higher incidence of CV events regardless of whether or not diabetes is present. In the UKPDS, targeting near-normal fasting glucose levels in newly diagnosed diabetes with a strategy starting with basal insulin or sulfonylurea reduced the 20-year risk of myocardial infarction and mortality by 15% and 13...

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During the 10-year UK Prospective Diabetes Study (UKPDS) post-trial monitoring period, sustained reductions were seen in the risks of diabetic complications, despite the previously randomised conventional and intensive treatment groups becoming identical with respect to median HbA1c values and glucose-lowering therapies. This continuing benefit of an earlier intervention in people with type 2 diabetes has been termed the ‘legacy effect’. A similar phenomenon seen in ...