Endocrine Abstracts

Brown adipose tissue (BAT) is a thermogenic organ. Its tremendous thermogenic potential is conferred by uncoupling protein 1 (UCP1), which dissociates ATP synthesis from energy substrate oxidation and thereby insures heat production. BAT represents a key thermogenic effector implicated in thermoregulatory thermogenesis. The physiological control of BAT activity and capacity is ensured by the sympathetic nervous system (SNS), which densely innervates brown adipocytes. SNS-media...

Background: Adipocytes and macrophages resident in adipose tissue produce and secrete a variety of biologically active mediators (adipokines) that contribute to the development of insulin resistance, type 2 diabetes mellitus and cardiovascular disease. Malfunction of adipocytes may play an important role in the development of low-grade inflammatory state associated with obesity.Objectives: Describe alternative ways to adipokines with potential impact on ...

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