Endocrine Abstracts

The tight coordinated regulation of food intake and energy expenditure represents the prerequisite for stable body weight control. Dysregulation of energy homeostasis, i.e. obesity represents a major and steadily growing health burden to western societies. The CN coordinates both the control of energy homeostasis, i.e. the balance of food intake and energy expenditure as well as peripheral fuel metabolism. Anatomical lesion experiments, pharmacological inhibition of signaling ...

In recent decades, a great deal of investigation has been focused on the role of gut hormones in energy homeostasis. The gastrointestinal tract is the largest endocrine organ in the body producing hormones that have important sensing and signalling roles in regulating body weight and energy expenditure. Dietary modifications are the first-line treatment for obesity however dieting results in only moderate weight-loss and maintenance of weight-loss is poor. Compensatory gut hor...

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