Endocrine Abstracts (2012) 29 P1291

The neuroendocrine complications of teenagers with diabetes insipidus of central genesis

SI. Ismailov, Yu M. Urmanova & U Kh Mavlonov


Tashkent Medical Pediatric Institute, Bukhara State Medical Institute, 223, Bogishamol Street, Tashkent 100125, Republic of Uzbekistan.


Aim: to study features of growth and development in teenagers with Diabetes Insipidus of central genesis.

Material and methods: During 2009–2010 years we examined 37 teenagers with Diabetes Insipidus of central genesis. 19 boys (51.3%) and 18 girls (48.6%) among them. Mean age of boys and girls was 13.5 years.

All patients underwent general clinical examination. Levels of STH, LH, FSH, prolactin, TSH, free thyroxin, cortisol, etc. were measured, biochemical (blood and urine analysis, Zimnitskiy test of urine), and roentgenologic investigations, such as, CT, MRI of Turkish saddle, hand X-ray, clinical ultrasound of the thyroid and genitals as well as anthropometric measurements on the base of international growth-weight chart of Tanner-Whitehouse with evaluation of centile, growth insufficiency, SDS of growth and weight, growth velocity were performed. The patients’ endocrine status was assessed with Tanner’s score to determine puberty stage.

We have comparison of our data with healthy teenagers (10 boys and 10 girls).

Results: We founded, that average centile was 50. Besides that, our patients have very big growth and weight insufficiency. The average growth insufficiency in boys was on our data 8.3±0.7 sm and 10.3±0.5 sm in girls. The weight insufficiency in boys was 7.3±0.5 kg and in girls 5.6±0.4 kg. We founded that growth SDS <−2, and weight SDS < -2 in boys and girls.

The evaluation of sexual development by Tanner’s stages showed, that in 18 cases from 37 (48.6%) was founded delay of puberty, in this cases in 10 boys (55.5%) and in 8 (44.4%) girls. Three boys have criptorhism.

All of our patients have delay of skeletal development and bone age/passport age was 0.7 in boys and girls. The average bone age was small on 2.7 years from chronological (passport) age.

The hormonal investigation showed, that more of our patients have insufficiency of pituitary hormones: STH – in 32 patients (86.4%), LH – in 28 (75.6%), FSH – in 28 (75.6%), TSH – in 15 (40.5%) with functional hyperrolactinemiya.

Conclusions: The stage of delay of puberty and growth in teenagers with Diabetes Insipidus directly correlated with condition of compensation of electrolytes, which submitted insufficiency of our pathogenetic therapy and decompensation of patient.

The evaluation of sexual development by Tanner’s stages showed, that in 18 cases from 37 (48.6%) was founded delay of puberty, in this cases in 10 boys (55.5%) and in 8 (44.4%) girls.

All of our patients have delay of skeletal development (100%).

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