Introduction: Production of chemerin (CHEM), omentin-1 (OMENT), and vaspin (VASP) in adipose tissue is determined by nutritional status. There is no data on CHEM, OMENT and VASP blood serum concentrations in patients with anorexia nervosa (AN).
Objectives: i) Assessment of CHEM, OMENT and VASP serum concentrations in girls with AN. ii) Analysis of correlations between the CHEM, OMENT, and VASP serum concentrations and body weight, BMI, serum insulin (INS) concentration in these patients.
Methods: Seventy-six girls: 46 with AN (mean age: 15.17±0.49 years; mean BMI: 15.34±0.55 kg/m2; mean BMISDS: −2.44±0.35) and 30 healthy (H; mean age: 15.4±0.8 years; mean BMI: 20.95±0.75 kg/m2; mean BMISDS: 0.131±0.41). CHEM, OMENT and VASP serum concentrations were determined by ELISA method and the INS by IRMA.
Results: The CHEM and INS average serum concentrations were significantly lower in AN group than in H group (130.24±2.15 ng/ml and 2.35±0.09 mIU/l vs 191.12±8.15 ng/ml and 4.24±0.2 mIU/l respectively, P<0.00001) but OMENT and VASP were higher (46.19±0.92 ng/ml and 0.52±0.01 vs 34.09±0.96 and 0.41±0.01 ng/ml, respectively, P<0.00001). In the AN group the negative correlation was found between CHEM concentration and body weight (r=−0.33, P<0.05), and INS and BMI (r=−0.31, P<0.05). The positive correlation between serum CHEM and INS, and negative relationship between serum OMENT and VASP concentrations and body weight as well as BMI in all subjects was found (P<0.00001).
Conclusions: In anorexia nervosa CHEM concentrations are decreased in comparison with healthy but OMENT and VASP are increased.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
05 - 09 May 2012
European Society of Endocrinology