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Endocrine Abstracts (2012) 29 P413

ICEECE2012 Poster Presentations Clinical case reports - Thyroid/Others (81 abstracts)

Vitamin D deficiency and elevation of para-thyroid in Thalassemia minor: a case study

S. Debnath


Women’s Polytechnic, Hapania, Govt. of Tripura, Agartala, India.


βThalassemia Minor cases unlike Thal-Major don’t require immediate medical attention, due to effective compensatory haematopoiesis and remain transfusion independent and patients may remain metabolically deficient lowering quality of life. To impose an artificial genetic bottleneck and suppress the dispersion of Thal-minor and Thal-major mutationsas in a population early detection is the only way out. Hypocholestreloemia, Vitamin D deficiency and marginally elevated Parathyroid hormone may be found in Thal-minors as reported in the case study. Absence of significant anaemia may make the condition cryptic or latent, delaying diagnosis of the condition and the situation may be complicate in longterm. Parathyroid level may be evaluated for secondary hyperparathyroidism due to deficiency of vitamin D. If several findings of Ca crystals (++/+) are present in urine RE, Bisphosphonate therapy may provide relief. This case study reports occurrence of pancreatic insufficiency, resultant steatorrhoea, Vitamin D (25-OH) deficiency (13.86 ng/ml) with Hypocholesterolemia (85 mg/dl). Para thyroid hormone was in upper limit (62 pg/ml) and Ca+2 was 9.5 mg/ml in a 30 years old male Thal-minor patient (fetal hemoglobin 2.10%, HbA2 4.60% and Hb Adult 84.80%).

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Table 1 Some diagnostic parameters of the patient case
Hematological profileEndocrineand related parameters profileSerum enzymesSerum anti bodiesMetabolic parameters and vitamin profileMinerals and electrolytes
Hemoglobin 13.8 mg/dl Para thyroid hormone 62 pg/mlSGPT 333 IU/mlAnti CCP antibody negativeF sugar 85 mg/dl Serum calcium was moderately low at 8.6 mg/dl
Reticulocyte count 1.08%Serum aldosterone 304.99 pg/mlAlk phos 400 IU/mlANA negativePP sugar 100 mg/dlSerum bi-carbonate moderaly elevated at 63 mmol
Fetal hemoglobin 2.10% Erythropoietin 22.80 mIU/ml CRP negativeTotal cholesterol 80 mg/dlSerum chloride WNR
HbA2 4.60%Homocysteine 11.97 μmol/lHbA1c was 5.60%Serum sodium WNR
Hb adult 84.80%TSH WNRTotal bilirubin 3 mg/dlSerum potassium was 5 mg/dl
TIBC was normal FT3 WNRTotal protein 6 mg/dl
First hour ERS 08 mm (Westergren)FT4 WNRVitamin B 12 level 466 pg/ml
TC of WBC 6900/ cm Urine osmolarity 295 mmol/kgFolic acid level 14.15 ng/ml
DLC WNRUrine volume 3560 ml/24 hVitamin D (25 OH) 13.86 ng/ml
Creatinie clearance was 117 ml/min 72 h stool fat was estimated to be 25.6 g
132 mg/dl protein excreted in 24 h
WNR - with in normal range for Indian males.

Volume 29

15th International & 14th European Congress of Endocrinology

European Society of Endocrinology 

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