Endocrine Abstracts (2012) 29 P908

Prevalence of elevated glycated hemoglobin in women with polycystic ovary syndrome: according to the recently defined criteria

S. Chae1, J. Kim2,3, Y. Choi2, K. Hwang2,4, S. Yoon5 & K. Kim2,3

1Maria Fertility Hospital, Seoul, Republic of Korea; 2Seoul National University College of Medicine, Seoul, Republic of Korea; 3Seoul National University Hospital, Seoul, Republic of Korea; 4Seoul National University Borame Medical Center, Seoul, Republic of Korea; 5Dongguk University Ilsan Hospital, Goyang, Republic of Korea.

Background: Insulin resistance is a core pathophysiology of polycystic ovary syndrome (PCOS). The screening recommendations for type 2 diabetes in PCOS patients have varied according to organizations, but the AE-PCOS Society recommended that a OGTT be performed in obese patients or in lean patients with advanced age (>40 year), with a history of gestational diabetes, or with a family history of type 2 diabetes. Recently, the American Diabetes Association (ADA) newly includes hemoglobin A1c (A1C) as a component of diagnostic criteria of ‘diabetes’ (≥6.5%) or ‘increased risk for diabetes’ (5.7–6.4%). This study was performed to examine the prevalence and the risk factors for elevated A1C (≥5.7%) in women with PCOS compared to age matched control women.

Methods: A1C was evaluated in 154 patients and 469 controls.

Results: One-third (31.2%) of the PCOS patients had elevated A1C. The prevalence of elevated A1C was similar in obese PCOS and obese controls (23.5 and 20.0%, respectively, P=1.0), but non-obese PCOS women (mean age 29.8±5.4 years) had a higher prevalence of elevated A1C than non-obese controls (31.2 vs 6.6%, respectively, P<0.001). The prevalence of elevated fasting plasma glucose was not different. The odds that a woman has an elevated A1C was 6.7 times higher if she has PCOS (adjusted OR 6.67, 95% CI 3.50–12.70).

Conclusions: Non-obese PCOS patients presented a significantly higher prevalence of elevated A1C than non-obese controls, whereas in obese subjects, the prevalence of elevated A1C was similarly elevated. Since substantial proportion of young and non-obese PCOS women are at an increased risk for diabetes, screening for type 2 diabetes may be necessary even in these young and non-obese PCOS patients. Future studies is mandatory to assess whether A1C is as effective as OGTT as a diagnostic tool in patients with PCOS.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This work was supported, however funding details unavailable.

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