Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2012) 29 P1274

ICEECE2012 Poster Presentations Obesity (114 abstracts)

Atherosclerosis risk factors before and 90 days after bariatric surgery

S. Polovina, M. Sumarac-Dumanovic, D. Bajec, D. Radenkovic, D. Stamenkovic-Pejkovic, J. Gligorijevic, D. Micic & D. Micic


Clinical Center of Serbia, Belgrade, Serbia.


Introduction: Morbid obesity is associated with systemic inflammation, possible impaired glucose toleration and changes in serum lipids. Association of these parameters is risk for atherosclerosis and cardiovascular diseases.

Methods: We have analyzed body weight, BMI, lipid profile, glucose, HbA1c and C reactive protein in 36 obese subjects, 8 males and 28 females, 37.9 (±18.6) years of age, before and three monts after bariatric surgery. There was performed laparoscopic restrictive-malapsorptive bariatric technique (Roux en Y gastric by pass). All of them were on 1200–1500 kcal balanced, medical nutritive therapy after surgery. Before surgery mean body weight was 130.4±44 kg, BMI 43±17.1 kg/m2, blood glucose 5.13±3.8 mmol/l, HbA1c 5.78%, total s-cholesterol 5.23 mmol/, HDL-C 1.15 mmol/l, LDL-C 3.04 mmol/l, triglycerids 2.11 mmol/l, CRP 13.3 mg/l.

Results: Three monts after bariatric surgery body weight loss was 23±9 kg, 17.6% (P<0.05), BMI decreased 5.9 kg/m2, 18% (P<0.05), glucose lowering was 1.5±1.4 mmol/l (P<0.05), HbA1c was lower 0.58, 12.3% (P<0.05). Changes in serum lipids was: s-cholesterol decreased 1.97 mmol/l, 37.6% (P<0.01), LDL-C 0.91 mmol/l, 29.1% (P<0.05), triglycerids 0.97 mmol/l, 42% (P<0.01). There was no significant changes in HDL cholesterol level and after 90 days HDL-C was 0.11 mmol/l lower, 9% (P>0.05). Decreasing in C reactive protein was 11 mmol/l, and that was most significant change of 82% (P<0.001).

Conclusion: Weight reduction due to bariatric restrictive-malabsorptive procedures and following medical nutritive therapy, improves lipid parameters, glycated hemoglobin, lowering systemic inflammation and risk for atherosclerosis and cardiovascular diseases in morbid obesity subjects.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Volume 29

15th International & 14th European Congress of Endocrinology

European Society of Endocrinology 

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