Endocrine Abstracts (2012) 29 P1777

Coexistence of chronic lymphocytic thyroiditis and well differentiated thyroid cancer-a prospective study

D. Askitis, E. Eufraimidou, M. Karanikas, A. Mitrakas, A. Polychronidis, G. Tripsianis & N. Lyrantzopoulos

University General Hospital of Alexandroupolis-Democritus University of Thrace-School of Medicine, Alexandroupolis, Greece.

Introduction: The coexistence of Hashimoto thyroiditis with welll differentiated thyroid carcinoma (DTC) has been discussed as far as the follow-up and prognosis of patients with chronic autoimmune thyroiditis (CAT) are concerned. The aim of our study was to find the coincident appearance of the two disorders in histologic specimens from patients who underwent total thyreoidectomy.

Material-Methodology: Between 2005–2010 228 patients (182 women/46 men) were operated with total thyroidectomy in our clinic. The surgical specimens were studied in the Pathology Department of our hospital.

Results: In 228 surgical specimens thyroid cancer was found in 33 (14.5%), from them 31 were DTC (13.6%),while elements of chronic lymphocytic thyroiditis were found in 56 (24.6%).Coexistence of Hashimoto and DTC was detected in 6 patients (19.3% of the DTC diagnosed patients, females/males 5/1). In the population of patients with autoimmune thyroiditis the cancer prevalence was 10.7%. There was no statistically significant difference as far as the age is concerned (P=0.677).

Conclusion: Further analytical clinical studies are required in order to establish a possible association between Hashimoto thyroiditis and DTC.Our results show that a careful examination and follow-up of the patients and mainly the women with the frequent diagnosis of the autoimmune thyroiditis is essential.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

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