ICEECE2012 Poster Presentations Thyroid cancer (108 abstracts)
Comparative examination of somatic oncogene mutation normal and pathologic thyroid tissues of Hungarian patients
B Tobiás , B. Balla , J. Kósa , J. Horányi , I. Takács , E. Bölöny , C. Halászlaki , Z. Nagy , G. Speer , B. Járay , E. Székely , R. Istók & P. Lakatos
Semmelweis University, Budapest, Hungary.
It is established that somatic oncogene mutation (BRAF, NRAS, HRAS, KRAS) and gene translocations (RET/PTC, PAX8/PPAR-gamma) are associated with the development of thyroid cancer. Somatic single nucleotide polymorphisms were analyzed by LigthCycler melting method, while translocations were identified by real-time polymerase chain reaction technique. In 22 intraoperative thyroid tissue samples (11 pathologic and 11 normal). In tumorous sample 3 BRAF, 2 NRAS and one HRAS mutations were found, as well as one RET/PTC1 translocation. These results confirm international data. These oncogene mutations and translocations are linked to thyroid cancer. Cytological examination completed with genetic data may support the diagnosis of thyroid malignancies. In addition, genetic alterations may indicate malignant transformation and may become prognostic factors in future.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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