Subcutaneous adipose tissue in women with polycystic ovary syndrome

A. Aydogdu; I. Tasci; O. Kucukerdonmez; S. Tapan; S. Aydogdu; G. Uckaya; C. Meric; Y. Basaran; A. Sonmez; C. Haymana; K. Baskoy; A. Taslipinar; O. Azal

The present study was performed to search whether SCAT increase in women with PCOS. Fifty-two women with PCOS patients and 53 matched healthy controls were participated in the study. Caliper device was used to measure skinfold thickness (SFT). Body fat distributions were determined by bioelectrical impedance analysis. SFT in all defined areas, total body and trunk fat free mass (FFM), and HOMA score were higher in women with PCOS, while adiponectin was significantly lower. SFT values correlated positively with HOMA score, and negatively with adiponectin. SFT in triceps and supscapular areas, trunk fat mass, trunk fat ratio, trunk fat mass and trunk fat free mass values were the most powerful predictors of HOMA score. In conclusion SCAT and FFM are increased in women with PCOS, with relation to insulin resistance.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Table 1 Clinical, endocrine and anthropometric measures of patients with PCOS and controls.
Variable	PCOS (n=52)	Control (n=53)	P
Age (year)	21.1±3.8	21.5±3.6	0.112
BMI (kg/m²)	24.3±5.3	22.2±2.3	0.430
WHR	0.7±0.1	0.7±0.04	0.264
Glucose (mg/dl)	87.4±8.4	81.0±5.9	0.0001
Total-C (mg/dl)	159.2±37.0	166.0±35.9	0.175
LDL-C (mg/dl)	89.9±27.2	98.2±28.6	0.140
HDL-C (mg/dl)	49.4±10.8	55.2±11.0	0.02
Triglyceride (mg/dl)	99.7±59.1	62.7±19.8	0.0001
LH/FSH	1.5±1.0	0.81±0.5	0.0001
Testosterone (ng/dl)	66.1±27.7	41.5±13.2	0.0001
HOMA-IR	2.3±1.2	1.2±0.5	0.0001
Adiponectin (μg/ml)	9.1±3.8	12.9±6.7	0.008
Total body fat free mass (kg)	45.3±5.6	42.9±2.7	0.005
Total body fat mass (kg)	19.4±8.9	16.6±4.8	0.610
Total body fat ratio (%)	28.6±7.5	27.4±5.1	0.341
Trunk fat ratio (%)	24.6±8.7	24.1±6.1	0.711
Trunk fat mass (kg)	9.0±4.8	7.9±2.9	0.610
Trunk fat free mass (kg)	25.6±3.2	24.2±1.5	0.003
MUAC (cm)	27.9±4.5	25.7±2.6	0.015
Biceps SFT (mm)	10.5±4.8	7.7±2.5	0.0001
Triceps SFT (mm)	16.5±5.6	13.7±4.3	0.0001
Supscapular SFT (mm)	15.9±6.5	13.0±3.6	0.032
Suprailiac SFT (mm)	17.4±6.7	13.7±4.4	0.003
BMI, body mass index; WHR, waist-hip ratio; HDL, high density lipoprotein; LDL, low density lipoprotein; C, Cholesterol; LH, Luteinizing hormone; FSH, Follicle stimulating hormone; DHEA-S, Dehydroepiandrosterone sulphate; HOMA, homeostasis model assessment; MUAC, mid-upper arm circumference; SFT, skin-fold thickness.

Endocrine Abstracts

P914