ICEECE2012 Poster Presentations Female Reproduction (99 abstracts)
Relation of hyperandrogenism and metabolic derangements in women with polycystic ovary syndrome
T. Bogavac 1 , D. Macut 1 , I. Bozic 1 , J. Bjekic-Macut 2 , B. Popovic 1 , M. Petakov 1 , S. Ognjanovic 1 , T. Isailovic 1 , V. Elezovic 1 & S. Damjanovic 1
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, Cinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2Clinical-Hospital Center ‘Bezanijska kosa’, Belgrade, Serbia.
Introduction: Polycystic ovary syndrome (PCOS) is associated with a higher risk for development of metabolic syndrome. In this study, we evaluated the degree of metabolic disorders in women with different PCOS phenotypes.
Methods: We analyzed 162 women with PCOS (BMI: 24.9±6.1 kg/m2, age:25.6±5.6 years) diagnosed on the basis of ESHRE/ASRM criteria, and 39 women without PCOS who comprised the control group (CG; BMI: 21.4±4.1 kg/m2, age: 28.4±5.4 years). Women with PCOS were divided into three subgroups according to the presence of hyperandrogenism (HA): A – with biochemical HA (n=97), B – with clinical HA (n=28), and C – without clinical or biochemical HA (n=37). In all subjects basal blood samples were collected in follicular phase of menstrual cycle for determination of glucose, insulin, total cholesterol (TC), HDL, LDL, triglycerides, apolipoproteins (Apo) A1, A2, B and E, lipoprotein (a), C-reactive protein (CRP), testosterone and SHBG. We used the standard formula to calculate HOMA, FAI, and lipid ratios TC/HDL, LDL/HDL, triglycerides/HDL, ApoB/ApoA1. PCOS and CG differed (P<0.01) in age and body mass index (BMI), and the calculations were done with the correction for these parameters.
Results: In PCOS subgroups, significant difference was found in concentrations of Apo A1 (P=0.017) due to the difference between subgroups A and C (1.49±0.24 vs 1.72±0.32 g/l). PCOS subgroup A had significantly higher (P<0.001) FAI index compared to subgroup B and C (A: 14.4±11.0%, B: 4.3±1.0%, C: 4.3±1.4%). FAI and ApoA1 had significant positive correlation (ρ=−0.32, P<0.01).
Conclusion: Women with hyperandrogenic PCOS phenotype have a significantly lower value of favorable ApoA1 in comparison to the PCOS phenotype without hyperandrogenism.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
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