ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2012) 30 P61

A prospective study of pubertal growth in children with inflammatory bowel disease

Avril Mason1, Salma Malik1, Martin McMillan1, Jane McNeilly3, Jonathan Bishop2, Paraic McGrogan2, Richard Russell2 & Faisal Ahmed1

1Developmental Endocrinology Research Group, University of Glasgow, RHSC Glasgow, Glasgow, UK; 2Department of Paediatric Gastroenterology, RHSC Glasgow, Glasgow, UK; 3Department of Paediatric Biochemistry, RHSC Glasgow, Glasgow, UK.

Background: Puberty is understood to be commonly affected in adolescents with Crohn’s disease (CD) and ulcerative colitis (UC).

Objective: To determine the impact of IBD on pubertal status and pubertal growth.

Methods: Single centre prospective study over 12 months of 45 adolescents (boys, 23) with CD and 18 (boys, 12) with UC with a median age of 13.4 years (10, 16.6). Assessment included details of disease, anthropometry and biochemical markers of growth and puberty at T0 and T12.

Results: Individually, 10/45 (22%) adolescents with CD had one or more parameter affected: 7 had a HtSDS at diagnosis <−2, 6 had HtSDS <−2 at 0 and 12 months. No subjects remained prepubertal beyond the age at which 97% of population would have expected to enter puberty and only two adolescents with CD showed a delay in progression through puberty. In the whole group, HV showed an inverse association with ESR (r,−0.286; P=0.025).

GroupHt0 SDSIGF1(0) SDSIGFBP3(0) SDSHV (cm/year)Change Ht SDSIGF1(12) SDSIGFBP3(12) SDS
CD−0.14 (−2.6; 2.1)−0.4 (−5.8; 2.6)0.45* (−1.5; 2.7)4.8 (0.2; 8.3)0.05 (−0.5; 0.6)−0.93** (−2.3; 0.9)1.91** (−1.9; 3.6)
UC0.25 (−1.8; 2.7)−0.5 (−2; 1.4)0.3 (−1.9; 1.6)5.4 (1.4; 8.7)0.16 (−0.5; 0.4)0.02 (−1.3; 1.0)1.3 (−2.0; 2.1)
*P<0.001; P<0.0001 as compared to the normal population.

At T0 post-pubertal boys with CD had median urinary luteinising hormone:creatinine and follicle stimulating hormone:creatinine ratios that were significantly lower than the healthy population (P=0.01 and P=0.0001).

Conclusion: As a group, disorders of the pubertal growth spurt are more likely to occur in CD. Achieving disease control may be important in attaining normal growth during puberty.

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