Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2012) 30 P61

BSPED2012 Poster Presentations (1) (66 abstracts)

A prospective study of pubertal growth in children with inflammatory bowel disease

Avril Mason 1 , Salma Malik 1 , Martin McMillan 1 , Jane McNeilly 3 , Jonathan Bishop 2 , Paraic McGrogan 2 , Richard Russell 2 & Faisal Ahmed 1


1Developmental Endocrinology Research Group, University of Glasgow, RHSC Glasgow, Glasgow, UK; 2Department of Paediatric Gastroenterology, RHSC Glasgow, Glasgow, UK; 3Department of Paediatric Biochemistry, RHSC Glasgow, Glasgow, UK.


Background: Puberty is understood to be commonly affected in adolescents with Crohn’s disease (CD) and ulcerative colitis (UC).

Objective: To determine the impact of IBD on pubertal status and pubertal growth.

Methods: Single centre prospective study over 12 months of 45 adolescents (boys, 23) with CD and 18 (boys, 12) with UC with a median age of 13.4 years (10, 16.6). Assessment included details of disease, anthropometry and biochemical markers of growth and puberty at T0 and T12.

Results: Individually, 10/45 (22%) adolescents with CD had one or more parameter affected: 7 had a HtSDS at diagnosis <−2, 6 had HtSDS <−2 at 0 and 12 months. No subjects remained prepubertal beyond the age at which 97% of population would have expected to enter puberty and only two adolescents with CD showed a delay in progression through puberty. In the whole group, HV showed an inverse association with ESR (r,−0.286; P=0.025).

T0T12
GroupHt0 SDSIGF1(0) SDSIGFBP3(0) SDSHV (cm/year)Change Ht SDSIGF1(12) SDSIGFBP3(12) SDS
CD−0.14 (−2.6; 2.1)−0.4 (−5.8; 2.6)0.45* (−1.5; 2.7)4.8 (0.2; 8.3)0.05 (−0.5; 0.6)−0.93** (−2.3; 0.9)1.91** (−1.9; 3.6)
UC0.25 (−1.8; 2.7)−0.5 (−2; 1.4)0.3 (−1.9; 1.6)5.4 (1.4; 8.7)0.16 (−0.5; 0.4)0.02 (−1.3; 1.0)1.3 (−2.0; 2.1)
*P<0.001; P<0.0001 as compared to the normal population.

At T0 post-pubertal boys with CD had median urinary luteinising hormone:creatinine and follicle stimulating hormone:creatinine ratios that were significantly lower than the healthy population (P=0.01 and P=0.0001).

Conclusion: As a group, disorders of the pubertal growth spurt are more likely to occur in CD. Achieving disease control may be important in attaining normal growth during puberty.

Volume 30

40th Meeting of the British Society for Paediatric Endocrinology and Diabetes

British Society for Paediatric Endocrinology and Diabetes 

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