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Endocrine Abstracts

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Society for Endocrinology BES 2013

Symposia

Making the glucocorticoid clock run smoothly (Supported by Addison's Disease self-help group)

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Sex in the brain (Supported by Endocrine Connections)
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Thyroid hormone receptors – mutations and implications (Supported by Journal of Molecular Endocrinology)

ea0031s6.1 | Making the glucocorticoid clock run smoothly (Supported by Addison's Disease self-help group) | SFEBES2013

Monitoring glucocorticoid signaling and circadian clock function with transgenic zebrafish reporter lines

Weger Benjamin D , Weger Meltem , Diotel Nicolas , Nusser Michael , Rastegar Sepand , Hirota Tsuyoshi , Kay Steve A. , Strahle Uwe , Brenner-Weiss Gerald , Dickmeis Thomas

Due to its rapid development and high fecundity, the zebrafish is a standard model in developmental biology and genetics. Furthermore, key hormone systems present in mammals are already active in zebrafish larvae. The endocrine system and the circadian clock are closely linked, and also the circadian system of zebrafish matures early in development. The small size of zebrafish larvae makes them particularly suitable for chemical screens in vivo: Larvae can be kept for...
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ea0031s6.2 | Making the glucocorticoid clock run smoothly (Supported by Addison's Disease self-help group) | SFEBES2013

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ea0031s6.3 | Making the glucocorticoid clock run smoothly (Supported by Addison's Disease self-help group) | SFEBES2013

Diurnal cortisol delivery: a novel tool for adrenal insufficiency

Ross Richard

Cortisol is an essential stress hormone and replacement with oral hydrocortisone is lifesaving in patients with adrenal insufficiency. Cortisol has a diurnal rhythm regulated by the central body clock and this rhythm is a metabolic signal for peripheral tissue clocks. Loss of cortisol rhythmicity is associated with fatigue, depression and insulin resistance. A general principle in endocrinology is to replace hormones to replicate physiological concentrations; however the pharm...
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ea0031s6.4 | Making the glucocorticoid clock run smoothly (Supported by Addison's Disease self-help group) | SFEBES2013

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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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