Endocrine Abstracts

cAMP is implicated in the regulation of a variety of cell functions that are related to activation of multiple intracellular pathways. In addition to the control of differentiated functions, such as hormone secretion, cAMP inhibits or stimulates cell proliferation depending on the cell type. In particular, consistent with the frequent expression of somatic mutations constitutively activating Gs alpha subunit (gsp oncogene) in GH-secreting adenomas, the activation of cAMP depen...

Anna Spada is currently Full Professor at the School of Medice, University of Milan. Her main research interests are on signal transduction in pituitary cells, pathogenesis of pituitary tumors, genotype/phenotype relationships in acromegalic patients with gsp mutations, tissue specific GNAS1 gene imprinting, molecular mechanisms of resistance to hormone action, activating and inactivating mutations of GNAS1 in endocrine disorders, polymorphic variants of somatostatin receptor ...