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Endocrine Abstracts

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15th European Congress of Endocrinology

Poster Presentations

Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>)

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Steroid metabolism and action

ea0032p840 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Early and sustained tumour volume reduction and GH/IGF1 control in patients with GH-secreting pituitary macroadenoma primarily treated with lanreotide Autogel 120 mg for 48 weeks: the PRIMARYS study

Caron Philippe , Bevan John , Clermont Antoine , Maisonobe Pascal

Introduction: First-line somatostatin analogue treatment may be an effective alternative option to surgery for some patients with GH-secreting pituitary macroadenoma. The PRIMARYS study aimed to investigate the impact of primary lanreotide Autogel 120 mg treatment on tumour volume and GH/IGF1 control in treatment-naïve acromegalic patients over a one-year time course.Methods: PRIMARYS was an international, multicentre, open-label, single arm, phase ...
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ea0032p841 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The benefits of pasireotide in patients with Cushing's disease are not restricted to patients with normalisation of UFC; results from a large, 12-month study

Pivonello Rosario , Petersenn Stephan , Gu Feng , Trovato Andrew , Hughes Gareth , Ligueros-Saylan Monica , Roberto Salgado Luiz , Lacroix Andre , Schopohl Jochen , Biller Beverly

Introduction: Pasireotide normalized or reduced UFC in patients with Cushing’s disease in a large, 12-month study. This analysis evaluates the effects of pasireotide on the signs/symptoms of Cushing’s disease according to the degree of UFC control.Methods: Adult patients (n=162) with persistent/recurrent or de novo Cushing’s disease were randomized to pasireotide 600/900 μg s.c. bid. Dose titration (max: 1200 μg...
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ea0032p842 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Exploration of hand size as a screening tool for acromegaly

Hackenberg Gudrun , Stormann Sylvere , Rommler Josefine , Rutz Sandra , Schopohl Jochen , Schneider Harald J

Introduction: There is a long delay between the onset of symptoms and correct diagnosis of acromegaly. This study aimed to explore the potential of hand size as a screening tool of acromegaly. Here we present first results of a new screening project.Method: We measured scan-copies of acromegalics (n=27, 9 women, age 18–84 years) and controls (n=111, 71 women, age 19–81 years) and analyzed surface areas of palm and thenar and m...
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ea0032p843 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The results of sandostatin LAR therapy in acromegalic patients

Galesanu Corina , Grozavu Ilinka , Loghin Andra , Florescu Alexandru , Haba Danisia

Introduction: Somatostatin analogs, formerly used as adjuvants in acromegaly treatment, are widely used as primary treatment today.Objective: To investigate the efficacy of octreotide therapy in acromegalic patients as primary or secondary therapy.Materials and methods: Four acromegalic patients diagnosed at the Endocrinological Clinic (males, mean age 35–75 years, age range 26–49 years, all patients with macroadenoma) we...
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ea0032p844 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Spanish molecular registry of pituitary adenomas: a multicenter, translational approach aimed at improving patient management

Leal-Cerro Alfonso , Luque Raul M , Sanchez-Tejada Laura , Ibanez-Costa Alejandro , Jorda Mireia , Galvez Maria A , Japon Miguel A , Rivero-Cortes Esther , Sanchez-Ortiga Ruth , Buj Raquel , Venegas Eva , Dios Elena , Webb Susan M , Soto-Moreno Alfonso , Fajardo Carmen , Bernabeu Ignacio , Benito-Lopez Pedro , Puig-Domingo Manel , Pico Antonio , Castano Justo P

Pituitary adenomas are heterogeneous, rare tumors, which hinders analysis of large numbers of cases with common approaches. To overcome this, a multicenter, clinical-basic strategy was proposed aimed at enhancing the tools to diagnose and manage pituitary tumors by combining clinical/pathological/molecular information. This initiative was developed by the Sociedad Andaluza de Endocrinología y Nutrición, and further endorsed by the Sociedad Española de Endocrinol...
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ea0032p845 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Pasireotide LAR and octreotide LAR maintain inhibition of GH and IGF1 in patients with acromegaly: 12-month extension phase of a randomized, double-blind, multicenter, phase III study

Sheppard Michael , Bronstein Marcello , Freda Pamela , Serri Omar , De Marinis Laura , Naves Luciana , Rozhinskaya Liudmila , Hermosillo Resendiz Karina , Ruffin Matthieu , Asubonteng Kobby , Colao Annamaria

Introduction: Pasireotide LAR was significantly superior to octreotide LAR at providing biochemical control in a 12-month trial in 358 medically naïve patients with acromegaly. Patients with clinical benefit or GH <2.5 μg/l and IGF1≤ULN could continue therapy in the extension study.Methods: Patients entering the extension (pasireotide LAR, n=74; octreotide LAR, n=46) were followed up to month 26 (core plus extension)...
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ea0032p846 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Characteristics of patients with pituitary gigantism: results of an international study

Rostomyan Liliya , Daly Adrian F. , Tichomirowa Maria , Naves Luciana A. , Shah Nalini , Chanson Philippe , Zacharieva Sabina , Stratskis Constantine A , Neggers Sebastian , Holdaway Ian , Stalla Gunter K. , Pronin Vyacheslav , Maiter Dominique , Bertherat Jerome , Colao Annamaria , Ilovaiskaya Irena , Ferone Diego , Zacharin Margaret , Salvatori Roberto , Beckers Albert

Aim: To analyse a large series of patients with pituitary gigantism.Materials and methods: We included in this multicentre study 158 patients (129 males) with pituitary adenoma (PA) or hyperplasia and current/previous abnormal, excessively rapid growth velocity for age or a final height greater than 2 SD above normal for their population. Data of patients were systematically recorded in case report forms.Results: The...
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ea0032p847 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Switching patients with acromegaly from octreotide LAR to pasireotide LAR improves biochemical control: crossover extension to a randomized, double-blind, multicenter, Phase III study

Freda Pamela , Fleseriu Maria , van der Lely Aart Jan , Colao Annamaria , Sheppard Michael , Gu Feng , Shen Chiung-Chyi , Gadelha Monica , Farrall Andrew , Hermosillo Resendiz Karina , Ruffin Matthieu , Chen YinMiao , Bronstein Marcello

Introduction: In a Phase III trial, pasireotide LAR was significantly superior (P=0.007) to octreotide LAR at providing biochemical control at 12 months in medically naïve acromegaly patients (post-pituitary surgery or de novo). Inadequately controlled patients (GH≥2.5 μg/l and/or IGF-1>ULN) at the end of core study were eligible for switching therapy (crossover extension). Reported here are efficacy results up to 12 months and safety resu...
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ea0032p848 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Advanced glycation end product associated skin autofluorescence and serum corboxymethyl lysine levels in acromegaly

Yavuz Dilek Gogas , Yalin Serap , Yazici Dilek , Yasar Mehmet , Deyneli Oguzhan

Aim: Nonenzymatic advanced glycation and oxidation end-products, advanced glycation end-products (AGEs), impart a potent impact on vessels in diabetic state and in euglycaemic conditions with increased oxidative stress.The aim of this study is to measure AGEs and its relationship with carotid intimae media thickness (CIMT) in acromegaly patients.Method: A case–control study was performed in 225 acromegalic patients (F/M: 116/1...
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ea0032p849 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The prevalence of insufficient test responses in patients with traumatic brain injury compared to healthy controls – results from The Danish National Study on posttraumatic hypopituitarism

Klose Marianne , Laurberg Peter , Frederiksen Louise , Stochholm Kirstine , Janukonyte Jurgita , Christiansen Jens Sandahl , Andersen Marianne , Feldt-Rasmussen Ulla

Introduction: We questioned the justification of general recommendations for assessment of hypopituitarism in patients with traumatic brain injury (TBI), and aimed to describe the prevalence of hypopituitarism in a national TBI population of patients admitted to a Danish hospital in 2008, as compared to healthy controls.Patients and methods: We included 463 patients (18–65 years) hospitalized ≥24 h, with more than subtle TBI as indicated by lo...
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ea0032p850 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Endoscopic transsphenoidal approach as a promising surgical option in the treatment of craniopharyngioma

Faustini-Fustini Marco , Zoli Matteo , Mazzatenta Diego , Santi Daniele , Brigante Giulia , Pasquini Ernesto , Frank Giorgio

Introduction: The management of craniopharyngioma (CR) remains a challenge. The introduction of endoscopic technique in the surgical approach to the sellar/suprasellar region would have profound implications for treatment. The aim of the study was to analyze results, advantages and limits of endoscopic endonasal approach (EEA).Design/methods: From 1998 to 2012, 95 patients underwent surgery for CR. Trancranial approach was chosen for 33 patients (35%) on...
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ea0032p851 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

A precocious GH peak at GHRH plus arginine test in GH sufficient short children is predictive of a lower growth velocity

Prodam Flavia , Castagno Matteo , Bellone Simonetta , Genoni Giulia , Giglione Enza , Marolda Agostina , Petri Antonella , Aimaretti Gianluca , Bona Gianni

Introduction: Generously supported by IPSEN)-->In children, GH secretion is considered sufficient when at least one value is >20 ng/ml at the GHRH + arginine (ARG) test. Because GH typically peaks at 45 min, we evaluated whether peak occurrence at one specific time is predictive of clinical outcomes in short stature children who are GH sufficient.Subjects and methods: Children who performed a GHRH plus ARG ...
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ea0032p852 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

A novel mutation in gonadotropin releasing hormone receptor causing delay in puberty in a sporadic case of isolated hypogonadotropic hypogonadism

Riaz Misbah , Mansoor Qaiser , Akram Maleeha , Shahbaz Madiha , Aslam Shaista , Mirza Shakeel , ullah Irfan , Akhtar Parveen , Qayyum Mazhar , Naseem Afzaal Ahmed , Tahir Fahim , Ismail Muhammad , Rizvi S S R

The signaling of G protein-coupled receptor 54 (GPR54) is a key regulator of the secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamic GnRH neurons, whereas GnRH is a crucial neurohormone regulating the secretion of FSH and LH at the time of puberty. The deficiency in the release or action of GnRH leads to hypogonadotropic hypogonadism (HH) characterized by low FSH, LH and testosterone (T) and results in absent or impaired sexual development at puberty. In b...
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ea0032p853 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Evaluation of late-night salivary cortisol during a Phase III study with pasireotide in patients with Cushing's disease

Newell-Price John , Petersenn Stephan , Pivonello Rosario , Findling James , Fleseriu Maria , Trovato Andrew , Hughes Gareth , Ligueros-Saylan Monica , Biller Beverly

Introduction: Generously supported by IPSEN)-->Measurement of salivary cortisol is a simple, convenient, accurate and reproducible technique with potential value during the diagnosis/management of hypercortisolism. Current analysis evaluates changes in late-night salivary cortisol (LNSC) during pasireotide treatment in patients with Cushing’s disease (CD).Methods: A 12 m, Phase III study enrolled 162 adult...
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ea0032p854 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Evaluation of long-term pituitary functions after hypoxia due to ventricular arrhythmias: a preliminary report

Tanriverdi Fatih , Simsek Yasin , Kaya Mehmet Gungor , Calapkorur Bekir , Diri Halit , Karaca Zuleyha , Unluhizarci Kursad , Kelestimur Fahrettin

Introduction: Traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), stroke and cerebrovascular disease (CVD) are identified as risk factors for hypopituitarism. However, the mechanisms and the risk factors for the hypothalamo-pituitary dysfunction due to TBI, SAH, stroke and CVD are still unclear (1,2,3). Hypoxia, hypoxemia, neuroinflammation, autoimmunity could have impact in the pathogenesis (4). In patients with serious ventricular arrhythmias who need resuscitation,...
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ea0032p855 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Long-term efficacy of long-acting somatostatin analogues in combination with pegvisomant in 112 acromegaly patients, a retrospective single centre study with follow up for up to 8 years

Franck Sanne , van der Lely Aart-Jan , de Rijke Yolanda , Neggers Sebastian

Introduction: Pegvisomant (PEGV) has an efficacy of >90% to control insulin-like growth factor (IGF-1), however in everyday practice a limited efficacy of 63% was reported.Aim: To assess efficacy in the largest single center cohort of acromegalics using PEGV.Methods: A 112 subjects (65 male) were not controlled with high-dose somatostatin analogues (LA-SRIF) for at least 6 months. To control acromegaly, 109 subjects added PEGV ...
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ea0032p856 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Long-term safety of long-acting somatostatin analogues in combination with pegvisomant in 133 acromegalic patients, a retrospective single centre study with follow up for up to 8 years

Franck Sanne , van der Lely Aart-Jan , Koole Rita , de Rooij Felix , Neggers Sebastian

Introduction: Pegvisomant (PEGV) has an efficacy of >90% to control insulin-like growth factor-1. Main safety issues are elevated transaminases that seem to be related to Gilbert’s polymorphisms (GiPism) or gender and tumor-size increase (1).Aim: To assess safety in the largest single center cohort of acromegalics using PEGV.Methods: Results are expressed as median (interquartile-range).One-hundred a...
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ea0032p857 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Similar response to therapy of pituitary adenomas with and without SOX2-expressing cells

Coculescu Mihail , Campean Anca , Stancu Cristina , Capatina Cristina , Livia Gheorghiu Monica , Caragheorgheopol Andra , Hortopan Dan , Ciubotaru Vasile , Raica Marius

Introduction: SOX2 is an early developmental transcription factor and a marker for pituitary progenitor cells.The study aimed to investigate if the pituitary adenomas with positive SOX2 immunoreactivity shows a different response to therapy as compared with controls.Patients and methods: We investigated 15 pituitary macroadenomas, eight with SOX2 immunoreactivity (SOX2+) and seven without (SOX2−) (controls); five were GH prod...
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ea0032p858 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The clinical characteristics of pain in patients with pituitary adenomas

Dimopoulou Christina , Athanasoulia Anastasia , Hanisch Erik , Held Stefanie , Toelle Thomas , Sprenger Till , Zieglgansberger Walter , Pfister Hildegard , Roemmler Josephine , Schopohl Jochen , Stalla Guenter , Sievers Caroline

Introduction: Clinical presentation of pituitary adenomas frequently involves pain, particularly headache, probably due to both structural and functional properties of the tumour.Design: In a retrospective analysis, we investigated clinical characteristics of pain in 277 patients with pituitary disease (n=81 acromegaly; n=50 Cushing’s disease; n=86 prolactinoma; n=60 non-functioning pituitary adenoma). Specific pa...
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ea0032p859 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Genetic and clinical characteristics of Serbian FIPA families

Miljic Dragana , Pekic Sandra , Stojanovic Marko , Dzeranova Nadezhda , Denes Judit , Gabrovska Plamena , Korbonits Marta , Popovic Vera

Introduction: Recently, major advances have been made in genetics of familial acromegaly and isolated pituitary adenoma (FIPA). Mutations in the aryl hydrocarbon interacting protein (AIP) gene have been found in 25–50% of patients with FIPA and familial acromegaly.Aim of the study: Our goal was to identify and collect data on patients who met the criteria for FIPA.Patients and methods: The patients were identified between 2008...
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ea0032p860 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Doubled mortality ratio in female patients with non-functioning pituitary adenomas

Galoiu Simona , Baciu Ionela , Ioacara Sorin , Gheorghiu Monica , Badiu Corin , Poiana Catalina , Coculescu Mihail

Introduction: Patients with non-functioning pituitary adenomas (NFPA) and hipopituitarism had a reduced life expectancy.Aims: To assess mortality ratio and to identify prognostic factors associated with mortality in patients with NFPA in the last decade.Methods: A 196 patients (83 F/113 M, mean age 52.7±0.9 years) with NFPA admitted in a single Neuroendocrinology Department between January 2001 and December 2010 were retrospec...
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ea0032p861 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Incidentally discovered pituitary adenomas: single-center experience on 205 patients

Malchiodi Elena , Ferrante Emanuele , Mantovani Giovanna , Toini Alessandra , Sala Elisa , Verrua Elisa , Giavoli Claudia , Filopanti Marcello , Spada Anna , Beck-Peccoz Paolo

Introduction: Pituitary incidentalomas are lesions discovered on an imaging study performed for an unrelated reason. Their frequency varies among 0.2–38% and it is continuously increasing due to the development of neuroimaging techniques. The aim of the study is to investigate clinical and biochemical characteristics of 205 consecutive patients (70% female, mean age 53.6±18.2 years) with incidental pituitary adenoma (IPA) followed at our center from 1990 to present.<...
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ea0032p862 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Clinical diagnostic implications of sequential pattern of dynamic MRI for pituitary microadenoma

Guo Qinghua , Erickson Dana , Young William , Bancos Irina , Erickson Bradley

Objective: We examined whether sequential enhancement patterns of pituitary microadenomas on dynamic MRI correlates with different subtypes of pituitary tumors.Materials and methods: Patients with pituitary microadenomas imaged via dynamic MRI between years 2000 and 2012 were included. The intensity of the adenoma and of normal gland at each time point in the dynamic sequence was measured by drawing a region of interest (ROI) on both the normal pituitary...
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ea0032p863 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

How to get surgical remission rates in ACTH- and GH-microadenomas to 100%

Ludecke Dieter , Flitsch Joerg , Crock Patricia , Saeger Wolfgang

Introduction: Pharmacological treatments are available for all functioning pituitary adenomas, but found to be only ideal in prolactinomas. Therefore, at least in ACTH- and GH-microadenomas we have to strive to achieve 100% remission with transnasal surgery. Our question is, which combination of an increasing arsenal of pre- and peri-operative methods will bring the pituitary surgeons to this result without increasing complications.Materials and methods:...
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ea0032p864 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Moderate hyponatremia is associated with an increased risk of overall mortality: a comprehensive meta-analysis

Corona Giovanni , Giuliani Corinna , Parenti Gabriele , Norello Dario , Verbalis Joseph G , Forti Gianni , Maggi Mario , Peri Alessandro

Introduction: Hyponatremia is the most common electrolyte disorder in clinical practice, and evidence to date indicates that severe hyponatremia is associated with increased morbidity and mortality. The aim of our study was to perform a comprehensive meta-analysis that included all the published studies that compared mortality rates in subjects with or without hyponatremia of any degree.Methods: An extensive Medline, Embase, and Cochrane search was perfo...
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ea0032p865 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of somatostatin analogues on muscle sympathetic nerve activity in acromegaly

Carzaniga Chiara , Seravalle Gino , Attanasio Roberto , Grassi Guido , Cozzi Renato , Maria Fatti Letizia , Montini Marcella , Vitale Giovanni , Sciortino Giovanna , Damanti Sarah , Scacchi Massimo , Mancia Giuseppe , Cavagnini Francesco , Persani Luca

Introduction: While searching for mechanisms contributing to the increased mortality of acromegaly, we have previously described an unexpected sympathoinhibition in newly diagnosed patients (Seravalle et al., Clin Endocrinol 77:262, 2012) and interpreted this finding as an adaptive phenomenon. It has also been shown that centrally administered somatostatin (SS) inhibits peripheral sympathetic outflow in rodents (Rettig et al., Am J Physiol 257:R588, 1989). Ba...
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ea0032p866 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of short (12 months) and long (60 months) term treatment with cabergoline on metabolic syndrome and visceral adiposity index in patients with hyperprolactinemia

Auriemma Renata S , Granieri Luciana , Perone Ylenia , Galdiero Mariano , Grasso Ludovica , Simeoli Chiara , Pivonello Claudia , Gasperi Maurizio , Giordano Carla , Colao Annamaria , Pivonello Rosario

Introduction: Hyperprolactinemia is reportedly associated with an impaired metabolic profile, particularly in patients with concomitant hypogonadism. The current study aimed at investigating the effects of short (12 months) and long (60 months) treatment with cabergoline (CAB) on metabolic complications, metabolic syndrome (MS) prevalence and visceral adiposity index (VAI) in hyperprolactinemic patients.Patients and methods: Seventy-one patients (51 F, 2...
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ea0032p867 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Real world data in acromegaly – a retrospective chart audit

Ferone Diego , Forsythe Anna , Ludlam William , Rondena Roberta , Thomas Cherry , Gadelha Monica

Introduction: The ideal strategy and the role of the different therapeutic options in acromegaly remain unclear. This research focuses on observing treatment options, and the respective level of disease control in acromegaly.Methods: A retrospective chart audit was conducted in US, France, Italy, and Brazil (September 2012). 97 endocrinologists completed structured case report forms for the 4 most recently-seen patients (two with somatostatin analogues (...
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ea0032p868 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Prevalence of escape and lipodystrophy in patients treated with Pegvisomant. A multicenter study

Sesmilo Gemma , Resmini Eugenia , Bernabeu Ignacio , Aller Javier , Soto Alfonso , Marazuela Monica , Mora Mireia , Pico Antonio , Fajardo Carmen , Torres Elena , Alvarez-Escola Cristina , Garcia-Centeno Rogelio , Blanco Concepcion , Camara Rosa , Gaztambide Sonia , Salinas Isabel , Del Pozo Carlos , Castells Ignasi , Villabona Carles , Webb Susan

Pegvisomant (peg) is an effective treatment for acromegaly.Aim: To investigate the prevalence of escape and the incidence of lipodystrophy with peg treatment.Methods: Multicenter retrospective study. Escape was defined as loss of control in patients previously controlled under a stable dose of peg, without any other treatment change. Lipodystrophy was defined as either hypertrophy or atrophy of subcutaneous tissue in areas of drug ...
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ea0032p869 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The effect of the ANKK1/DRD2 Taq1A polymorphism on metabolic side effects of dopaminergic treatment in PRL adenomas

Athanasoulia Anastasia P , Sievers Caroline , Uhr Manfred , Stalla Gunter , Schneider Harald

Introduction: Treatment with dopamine agonists in patients with PRL adenomas has been associated with weight loss in short-term studies. However, long-term studies on weight changes are lacking. Taq1A is a restriction fragment length polymorphism considered as a gene marker for the D2DR gene. The presence of at least one A1 allele is linked to reduced brain dopaminergic activity due to reduced receptor binding and lower density of the dopamine two receptor.<p clas...
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ea0032p870 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Incidental haemorrhage in prolactinomas: is it of any clinical significance?

Sarwar Komil , Huda Bobby , Van-de-Velde Vanessa , Hopkins Laura , Luck Sara , Preston Rebecca , McGowan Barbara , Carroll Paul , Powrie Jake

Background: Incidental pituitary haemorrhage in prolactinomas is a common radiological finding. The clinical significance, associations and outcome of this are largely unknown. Most reports describe surgically treated macroprolactinoma and non-functioning adenoma, and there are few data in a clinic prolactinoma population.Aims: To characterise the prevalence, natural history and risk factors associated with pituitary haemorrhage in a large clinic prolact...
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ea0032p871 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Incidence of pituitary adenomas in Western Sweden in 2001–2011

Gunnarsson Kerstin , Tjornstrand Axel , Evert Max , Holmberg Erik , Norrman Lise-Lott , Rosen Thord , Ragnarsson Oskar , Nystrom Helena Filipsson

Background: The number of studies on the incidence of pituitary adenomas (PAs) is limited. The aim of this study was to evaluate the annual incidence of PAs in Västra Götaland, Sweden, with a targeted population of 1.6 million inhabitants.Patients and methods: Data from adult patients diagnosed with PA in 2001–2011, living in the Västra Götaland County, were collected from the Swedish Pituitary Registry (SPR). In addition, medica...
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ea0032p872 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Ursodeoxycholic acid role in chronic cholecystitis progression prevention in acromegaly patients receiving somatostatin analogues

Poteshkin Yuriy , Pronin Vyacheslav , Pronin Evgeny , Kotlyarevskaya Evgenia , Morozova Maria

Introduction: Acromegaly – a serious debilitating disease resulting in decreased quality and length of life. Due to the late nature of the diagnosis, the lack of prospects for a surgical or non-radical adenomectomy leads to a somatostatin analogues (SA) treatment as primary or secondary therapy, which is a long-term, sometimes lifelong. Therefore, the question of tolerability and prevention of life-threatening complications for these patients is very important. Since the ...
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ea0032p873 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Relationship between telomere length and dyslipidemia in patients with Cushing's syndrome

Aulinas Anna , Jose Ramirez Maria , Jose Barahona Maria , Mato Eugenia , Bell Olga , Valiente Cristian , Valassi Elena , Resmini Eugenia , Santos Alicia , Crespo Iris , Corcoy Rosa , Surralles Jordi , Webb Susan M.

Introduction: Cushing’s syndrome (CS) is associated with increased mortality and morbidities. Hypercortisolism is also present in chronic mood disorders (CMD) and stress, where telomere length (TL) has been found to be shorter than in matched controls. Since hypercortisolism is present in CS and CMD, we hypothesized that telomere shortening could also be present in CS. The aim of this study was to investigate TL in CS patients compared to matched controls.<p class="ab...
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ea0032p874 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Factors Affecting Prognosis in a Series of Acromegalic Patients

Fusco Alessandra , Bianchi Antonio , Giampietro Antonella , Iacovazzo Donato , Lugli Francesca , Chiloiro Sabrina , Piacentini Serena , Tartaglione Linda , Doglietto Francesco , Anile Carmelo , Maira Giulio , De Marinis Laura

Introduction: The main goal in the treatment of acromegaly is achieving biochemical and tumor mass control. Therapeutic options include surgery, medical treatment and, in selected cases, radiotherapy. A GH receptor (GHR) variant that differs for the genomic retention or exclusion (d3GHR) of exon 3 is present in about 50% of general population and its presence is related to a greater sensitivity to GH.Materials and methods: We describe a series of 118 pat...
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ea0032p875 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Thirty-day mortality in acute non-surgical patients admitted with hyponatremia

Holland-Bill Louise , Christiansen Christian , Ring Troels , Toft Sorensen Henrik , Lunde Jorgensen Jens Otto

Introduction: Hyponatremia (serum sodium ≤135 mmol/l), the most common electrolyte disorder encountered, has been associated with increased mortality in patients with particularly cancer, heart failure, chronic kidney and liver disease. However, evidence of the clinical implications in broader populations is scarce, and uncertain due to confounding from preexisting disease. We aimed to examine the association between admission-hyponatremia and 30-day mortality in acute n...
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ea0032p876 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Metabolic impact of IGF(CA)19 gene polymorphism on the response to GH therapy in adult GH-deficient (GHD) patients

Giavoli Claudia , Profka Eriselda , Sala Elisa , Filopanti Marcello , Bergamaschi Silvia , Ferrante Emanuele , Arosio Maura , Ambrosi Bruno , Spada Anna , Beck-Peccoz Paolo

Generously supported by IPSEN)-->A highly polymorphic microsatellite in the IGF-I gene promoter composed of variable cytosine–adenine (CA) repeats (n=10–24) has been linked to IGF-I levels, risk of diabetes and cardiovascular diseases with conflicting results. Aim of this study was to investigate the impact of this polymorphism on the response to rhGH (mean dose 0.34±0.14 mg/day) in adult GH-deficient (GHD) pa...
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ea0032p877 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Hypopituitarism after fractionated stereotactic radiation therapy of anterior skull base meningiomas is caused by mass effects, not radiation

Moeller Emil , Astradsson Arnar , Klose Marianne , Roed Henrik , Feldt-Rasmussen Ulla , Juhler Marianne

Introduction: Fractionated stereotactic radiotherapy (FSRT) is used in the treatment of surgically inaccessible meningiomas, primarily in the base of the skull. Development of hypopituitarism following FSRT is inexhaustively investigated. We aimed to elucidate the cause of hypopituitarism in patients treated with FSRT for benign meningiomas of the anterior skull base.Methods: All patients undergoing FSRT for benign meningioma of the skull base between Ju...
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ea0032p878 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Role of IGF(CA)19 gene polymorphism in the clinical presentation of acromegaly

Sala Elisa , Mantovani Giovanna , Ferrante Emanuele , Barbieri Anna Maria , Malchiodi Elena , Verrua Elisa , Giavoli Claudia , Filopanti Marcello , Beck-Peccoz Paolo , Spada Anna

Introduction: A highly polymorphic microsatellite, comprising a variable length of a cytosine–adenosine (CA) repeat sequence, has been identified in the promoter region of IGF-I gene. The number of CA repeats ranges between 10 and 24 and the most common allele in the Caucasian population contains 19 CA (192 bp) repeats. Several studies investigated the relationship between this polymorphism and IGF-I levels, with conflicting results. Aim of this study was to investigate t...
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ea0032p879 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Relationship between early endocrine alterations and functional outcome in patients with severe brain injury

Marina Djordje , Klose Marianne , Nordenbo Annette , Liebach Annette , Westergaard Lars , Feldt-Rasmussen Ulla

Introduction: Recently, it has been suggested that hypopituitarism developed after the brain injury has implications in the final recovery of the patients. We hypothesize that hypopituitarism developed in the course of traumatic brain injury (TBI) or non-TBI is related to worse functional outcome. The aim was to assess the association between hypopituitarism in the early recovery phase and long-term functional outcome.Materials and methods: We included 1...
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ea0032p880 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Limitations of basal IGF-1 status reflecting the severity of growth hormone deficiency and predicting response to replacement therapy

Perez Laura , Parra Paola , Fernandez Alberto , Guillen Maria Augusta , Pallardo Luis Felipe , Alvarez Cristina

Generously supported by IPSEN)-->GH replacement (GHR) in adults has demonstrated to improve body composition, inflammatory cardiovascular biomarkers and quality of life. However, this benefit is uneven, and factors that stratify treatment response are required.According to current guidelines, low IGF-I levels in specific conditions provide strong evidence for GH deficiency (GHD). Nevertheless, normal levels do ...
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ea0032p881 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of gender and body composition on GH response to GHRH+Arg in HIV-lipodystrophic patients: higher rate of GH deficiency in men

Brigante Giulia , Diazzi Chiara , Ferrannini Giulia , Ansaloni Anna , Zirilli Lucia , Guaraldi Giovanni , Rochira Vincenzo

Background: SUB:Pituitary – Clinical (Generously supported by IPSEN)GH response to GHRH+Arg is impaired in HIV-infected men and women, compared to gender matched controls. Moreover, reduced GH secretion seems to occur more frequently in HIV-infected males than females.Methods: To determine gender effects on GH secretion in HIV-infected patients with lipodystrophy, we compared GH/IGF1 status and body composition in 103 males and 97 females. ...
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ea0032p882 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Obesity in patients with craniopharyngioma seems to be caused by eating disorders rather than changes in mood or activity

Roemmler Josefine , Geigenberger Veronika , Dimopoulou Christina , Sievers Caroline , Stalla Guenther , Schopohl Jochen

Introduction: SUB:Pituitary – Clinical (Generously supported by IPSEN)It is still unclear whether obesity in craniopharyngioma (CP) is caused by disorders in food regulation or by changes in mood or activity due to depression or sleepiness leading to a decrease in energy consumption. We compared CP to patients with non-functioning pituitary adenoma (NFPA) by using standardized questionnaires to clarify this question.Methods: We compared 31 ...
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ea0032p883 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Correlation of clinical smell test and magnetic resonance imaging of olfactory system in idiopathig hypogonadotropic hypogonadism

Kota Sunil Kumar , Meher Lalit Kumar , Jammula Sruti , Modi Kirtikumar D

Objectives: i) To measure olfactory bulbs and sulci using dedicated magnetic resonance imaging (MRI) sequences in idiopathic isolated hypogonadotropic hypogonadism (IHH) patients with a well detailed phenotype characterization. ii) To correlate MRI findings with a clinical smell test.Methods: SUB:Pituitary – Clinical (Generously supported by IPSEN)MRI was performed in 20 patients (all males, aged between 11 and 45 years, mean age of 26) wit...
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ea0032p884 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Diencepephalic syndrome before diagnosis of childhood craniopharyngioma: results of multinational studies on 485 long-term survivors after childhood craniopharyngioma

Hoffmann Anika , Sterkenburg Anthe , Gebhardt Ursel , Muller Hermann

Background: SUB:Pituitary – Clinical (Generously supported by IPSEN)Hypothalamic involvement (HI) resulting in severe obesity is known to have major impact on quality of life in craniopharyngioma (CP) patients. HI is also associated with disturbances of satiety regulation leading to a failure to thrive and weight loss known as diencephalic syndrome (DS). The rate of DS and the outcome of CP patients with DS is unknown.Methods: CP patients h...
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ea0032p885 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Xanthogranuloma, Rathke‘s cyst, and Childhood Craniopharyngioma: results of prospective multinational studies of children and adolescents with rare sellar malformations

Muller Hermann , Gebhardt Ursel , Faldum Andreas , Warmuth-Metz Monika , Pietsch Torsten , Pohl Fabian , Calaminus Gabriele , Sorensen Niels

Background: SUB:Pituitary – Clinical (Generously supported by IPSEN)Craniopharyngioma (CP), Rathke’s cyst (RC) and xanthogranuloma (XG) are closely related rare sellar masses, which share common embryogenic origin. Treatment strategies in children lack consensus, especially in terms of surgical and radiooncological treatment options.Objective: To study clinical manifestations and treatment-related outco-me in RC, XG, and CP patients.</...
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ea0032p886 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Short-term exercise-induced GH response in athletes: differential results for runners and bikers when tested on bicycle

Zueger Thomas , Bucher Julie , Christ Emanuel , Stettler Christoph

Background/introduction: SUB:Pituitary – Clinical (Generously supported by IPSEN)We have previously shown that GH assessment during a standardized aerobic exercise of moderate intensity is a reliable test with high diagnostic accuracy in predicting severe GH deficiency (GHD) in adult individuals. However, these studies comprised comparably long exercise durations around 60 min or longer. To improve clinical applicability of exercise testing in the diagnosis of GH...
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ea0032p887 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Gender determines ACTH recovery after experimental hypercortisolemia in older individuals

Sharma Animesh , Aoun Paul , Wigham Jean , Weist Sue , Veldhuis Johannes

Introduction: Available clinical literature raises the possibility that stress-responsive mechanisms differ by gender, especially in older individuals; however the accompanying evidence is both limited and discrepant. We hypothesize that gender determines the degree of ACTH inhibition by and recovery after an experimental cortisol clamp in older subjects.Subjects and design: We conducted a prospectively randomized, double-blind, placebo-controlled, cross...
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ea0032p888 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Levels of prolactin, FSH and LH pool vs single sample determination

Belo Sandra , Souto Selma , Magalhaes Angela , Carvalho Davide , Guimaraes Joao Tiago

Introduction: The assessment of pituitary function is often achieved by means of sequential determinations (pool) of hormone levels such as prolactin and gonadotrophins. For the determination of prolactin levels the guidelines of the Endocrine Society are clear in recommending a single sample determination.Objective: To evaluate differences between single sample and pool (0′, 20′ and 60′) determinations for assessing prolactin, FSH and ...
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ea0032p889 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Tumors with simultaneous hypersecretion of somatotropin and prolactin are associated with earlier diagnosis compared with tumors with isolated hysecretion of somatotropin

Belo Sandra , Nogueira Claudia , Magalhaes Angela , Vinha Eduardo , Pereira Josue , Carvalho Davide

Introduction: Amenorrhoea and galactorrhoea are manifestations that may allow earlier diagnosis of pituitary tumors associated with excess somatotropin (ST) and prolactin (PRL) levels.Objective: To evaluate clinical, analytical and imaging characteristics of ST and PRL producing tumors and its affect on diagnosis.Methods: Retrospective study including acromegalic patients diagnosed between 1982 and 2012. Information on clinical, an...
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ea0032p890 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Macroprolactinomas: dopamine agonists for how long?

Santos Maria Joana , Almeida Rui , Marques Olinda

Introduction: Generously supported by IPSEN)-->Dopamine agonists (DA) effectively normalize prolactin secretion and reduce tumour size in most patients with macroprolactinomas. However, some patients are considered partially/totally resistant. Some authors propose that patients treated for 2 years, with normal prolactin secretion with low dose AD and maximal tumour diameter reduction >50%, could suspend treatment, but relapse rat...
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ea0032p891 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Role of reversal of hypogonadism on the improvement of metabolic syndrome in male patients with hyperprolactinemia during chronic treatment with cabergoline

Galdiero Mariano , Auriemma Renata S , Calzo Fabio Lo , Vitale Pasquale , Pivonello Claudia , Cariati Federica , Perone Ylenia , Salzano Ciro , Colao Annamaria , Pivonello Rosario

Introduction: Generously supported by IPSEN)-->Hyperprolactinemia (HPRL) is associated with an impaired metabolic profile, particularly in patients with hypogonadism. This study aimed to: i) investigate the effects of short and long treatment with cabergoline (CAB) on the prevalence of metabolic syndrome (MS) and insulin sensitivity and ii) to evaluate the impact of gonadal function on metabolic changes, in male patients with HPRL.</...
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ea0032p892 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Measurement of hGH in acromegalic patients under pegvisomant treatment

Purice Mariana , Gheorghiu Monica , Jercalau Simona , Badiu Corin

Generously supported by IPSEN)-->Treatment with hormone analogues can challenge the precise measurement by interference with the routinely used immunoassays systems, related to the presence of autoantibodies in the serum, interference with associated therapy or the presence of altered forms of the hormone, with modified biological activity and/or immunoreactivity.In patients with acromegaly treated with the hGH...
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ea0032p893 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Myeloproliferative neoplasms in patients with acromegaly

Isailovic Tatjana , Beleslin Bojana , Lalic Nebojsa , Lukic Ljiljana , Popovic Bojana , Petakov Milan , Macut Djuro , Ognjanovic Sanja , Elezovic Valentina , Bozic Ivana , Bogavac Tamara , Ilic Dusan , Pekmezovic Tatjana , Damjanovic Svetozar

Introduction: Generously supported by IPSEN)-->The coexistence of acromegaly and secondary polycythemia has been described in a few patients. This association was ascribed to GH/IGF1 proliferative effect on bone marrow progenitor cells. In contrast, the presence of myeloproliferative neoplasm (MPN) with documented JAK2 mutation so far has been described in only one acromegalic patient.Methods: We analyzed the p...
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ea0032p894 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Familiar panhypopituitarism by a mutation in PROP1: four of seven brothers affected

Lau Eva , Freitas Paula , Coutinho Eduarda , Lemos Manuel , Carvalho Davide

Introduction: Generously supported by IPSEN)-->PROP1 (Prophet of Pit-1) mutations are the most frequent genetic cause of panhypopituitarism, a condition associated with a deficiency or inadequate production of hormones of the anterior pituitary. The PROP1 gene encodes a transcription factor involved in the ontogeny, differentiation and function of somatotrophs, lactotrophs and thyrotrophs. These mutations are characterized by a remar...
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ea0032p895 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Cushing's disease in children – the effectiveness and complications of transsphenoidal surgery

Witek Przemyslaw , Zielinski Grzegorz

Introduction: Generously supported by IPSEN)-->ACTH-secreting pituitary adenomas are the most common cause of endogenous hypercortisolemia in children after 10 years of age. In spite of this pediatric Cushing’s disease (pCD) is a rare medical condition. Transsphenoidal surgery (TSS) remains the treatment of choice but – according to literature date – results of such a procedure could be worse comparatively to adult pop...
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ea0032p896 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effect of treatment outcome on co-morbidities of Cushing's disease

Assimakopoulou Athina , Tzanela Marinella , Palimeri Sotiria , Karapanou Olga , Botoula Efi , Tsagarakis Stylianos

Generously supported by IPSEN)-->Endogenous hypercortisolism leads to increased morbidity and mortality. As Cushing’s disease (CD) is a rare disorder, data on co-morbidities outcome after current treatment interventions are scarce.We studied 78 patients with CD (67 females, 11 males, mean age 42.2±1.4 years), with a follow up of 90.8±7.8 months. All patients underwent transsphenoidal surgery (TSS...
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ea0032p897 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Serum GH but not IGF1 levels correlate with body composition parameters in both men and women with active acromegaly

Stojanovic Marko , Miljic Dragana , Pekic Sandra , Doknic Mirjana , Popovic Vera

Introduction: Generously supported by IPSEN)-->Active acromegaly is reported to be associated with considerable body composition changes, with significant lean body mass changes found only in men.Patients and methods: In patients with active acromegaly (n=40) 24 females and 16 males, 48.9±6.4 years old, with BMI of 28.04±1.27 kg/m2, diagnosed 4.15±1.09 years ago, body composit...
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ea0032p898 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Receptor expression in craniopharyngiomas causing tumor growth in pregnancy: case report and review of the literature

Monica Tome , Laurent Vroonen , Albert Thiry , Adrian Daly , Albert Beckers

Introduction: Generously supported by IPSEN)-->Craniopharyngiomas (CP) are benign tumors that arise from remnants of the Rathke’s pouch. Classically, they are classified as cystic or calcified tumors. The presence of hormonal receptors in CP has been reported in in vitro studies but only eight cases growing during pregnancy have been published in literature.Case report: We report a 32-year-old wom...
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ea0032p900 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Increased thyroid cancer risk in acromegaly

Dagdelen Selcuk , Cinar Nese , Erbas Tomris

Introduction: Generously supported by IPSEN)-->Acromegaly increases cancer risk. We aimed to determine the prevalence and the predictors of tumors in acromegalic patients treated at our department.Design: We retrospectively evaluated 142 acromegalic patients (75 females (mean age 52.1±10.4 years and 67 males (mean age 49.4±12.7 years)) treated at university center, endocrinology outpatient clinic betw...
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ea0032p901 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Efficacy and safety of lanreotide in combination with pegvisomant in clinical practice in patients with active acromegaly with monotherapy failure

Venegas Eva , Lucas Tomas , Marazuela Monica , Cuatrecasas Guillem , Galvez Maria Angeles , Romero Enrique , Morales Francisco , Webb Susan M , Biaggeti Betina , Diaz Juan Jose , Mato Jose Antonio , Vilchez Ricardo , Bernabeu Ignacio , Paja Miguel , Pico Antonio , Domingo Manuel Puig , Soto Alfonso , on behalf of ACROCOMB study group

Introduction: ACROCOMB is a retrospective Spanish Multicenter study, designed to evaluate the efficacy (extent of tumour control) and safety of lanreotide (LAN) treatment combined with pegvisomant (PEG) or cabergoline in acromegalic patients with monotherapy failure.Methods: patients with acromegaly treated with LAN+PEG (45% of ACROCOMB patients) at 44 Spanish Endocrinology Departments were analysed.Results: 40% of patients were ma...
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ea0032p902 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Efficacy and safety of lanreotide in combination with cabergoline in clinical practice in patients with active acromegaly with monotherapy failure

Vilchez Ricardo , Bernabeu Ignacio , Blanco Concepcion , Cordido Fernando , Paja Miguel , Casany Rosa , Fajardo Carmen , Maraver Silvia , Martin Tomas , Lucas Tomas , Arnes Juan Antonio Garcia , Catalina Pablo Fernandez , Icaya Maria Purificacion Martinez de , Sesmilo Gemma , Pico Antonio , Marazuela Monica , Soto Alfonso , Domingo Manuel Puig , on behalf of ACROCOMB study group

Introduction: ACROCOMB, a retrospective Spanish Multicenter study, evaluated the efficacy and safety of lanreotide (LAN) combined with cabergoline (CAB), or pegvisomant in patients with acromegaly.Methods: patients treated with LAN+CAB at 44 Spanish Endocrinology Departments were included.Results: 33% male patients, median age: 50.4 years. Mean time from diagnosis: 5.9±6.9 years. Tumour size at diagnosis: 21.9 mm. 83% of patie...
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ea0032p903 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Efficacy of hGH treatment in pituitary dwarfism- age does matter

Idriceanu Jeanina , Vasiliu Ioana , Popovici Ramona , Bodescu Ioana , Rusu Cristina , Mogos Voichita , Vulpoi Carmen

Introduction: The spectrum of GH deficiency (GHD) in children ranges from complete deficiency, with severe growth retardation, to partial deficiency, with slightly short stature. The administration of GH to children with GHD improves linear growth, mainly during the first 2 years of treatment.Patients and methods: The study analyzes pattern of growth in 35 children (24 boys, 11 girls) with GHD, in the first year of treatment with hGH. There were three gr...
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ea0032p904 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Clinical, hormonal and radiological characteristics of a group of primary empty sella patients

Gedik Arzu , Yilmaz Merve , Demir Tevfik , Bayraktar Firat , Men Suleyman , Eraslan Sevinc , Comlekci Abdurrahman

Background: Primary empty sella is an anatomical term defining the herniation of subarachnoid space within the sella turcica without an underlying factor such as pituitary tumor, surgery, irradiation or trauma.Patients and methods: We retrospectively evaluated clinical, hormonal and radiological data of the patients with primary empty sella syndrome followed in our institution between 2001 and 2012.Results: Ninety-four patients (80...
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ea0032p905 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The effects of cabergoline treatment on cardiac valves in patients with prolactinoma

Sarac Fulden , Sarac Sefa , Tutuncuoglu Pelin

Introduction: Dopamine agonists have been reported to increase the risk of cardiac valve regurgitation in valve disease risks for 3 years treatment with cabergoline in patients with prolactinma. The aim of the study was to evaluate the frequency of cardiac valve diseases and regurgitation in patients with prolactinoma at the end of 3 years.Subjects and method: Thirty-one patients with prolactinoma who had received cabergoline following 3 years were enrol...
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ea0032p906 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Treatment with pasireotide LAR normalizes prolactin levels in patients with acromegaly and hyperprolactinemia: randomized, double-blind, 12-month, phase III study

Colao Annamaria , Freda Pamela , Gu Feng , Resendiz Karina Hermosillo , Ruffin Matthieu , Chen YinMiao , Bronstein Marcello

Introduction: Around 20–30% of patients with acromegaly have hyperprolactinemia, which is associated with infertility and gonadal/sexual dysfunction. Current therapy involves somatostatin analogues for GH/IGF1 excess and a dopamine agonist to decrease prolactin levels. The objectives of this analysis were to assess treatment with pasireotide LAR or octreotide LAR alone in patients with acromegaly and hyperprolactinemia.Methods: Patients with acromeg...
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ea0032p907 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Characteristics and outcomes of the Italian subpopulation enrolled in the observational, multicenter hypopituitary control and complications study (HypoCCS)

Aimaretti Gianluca , Ferone Diego , Ambrosio Maria Rosaria , Beck-Peccoz Paolo , Cannavo Salvatore , Colao Anna Maria , Losa Marco , Martinez Beverly Festin , Marchi Paolo , Vottero Alessandra

Aim: To describe characteristics and outcomes of Italian patients with hypopituitarism participating in HypoCCS.Methods: Study population was stratified by max GH peak (mGHp) and BMI. Baseline variables included demographic characteristics, type of deficit, smoking habits; variables analyzed over time included weight, Framingham cardiovascular disease (CVD) risk, lipids, GH dose.Results: Italian subpopulation included 342 patients ...
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ea0032p908 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Sleep-apnea and cardiomyopathy in acromegalic patients

Sanchez-Ortiga Ruth , Candela Alfredo , Climent Vicente , Sanchez-Tejada Laura , Monjas-Canovas Irene , Abarca Javier , Moreno-Perez Oscar , Pico Antonio

Introduction: Sleep disordered breathing (SDB) promotes structural myocardial changes and can trigger cardiac arrhythmias. Acromegalic patients have high prevalence of SDB and GH–IGF1 excess is related to a specific cardiomyopathy characterized by concentric cardiac hypertrophy and diastolic dysfunction. The aim of this study was to assess the relationship between SDB and cardiac dysfunction on acromegalic patients.Material and methods: Observationa...
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ea0032p909 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

PONV prophylaxis alters postoperative cortisol-measurement in transphenoidal pituitary surgery

Burkhardt Till , Rotermund Roman , Kiefmann Rainer , Westphal Manfred , Flitsch Jorg

Objective: Postoperative nausea and vomiting is common after general anaesthesia and is reported by ~20–25% of all patients. The standard prophylaxis at the authors department is a single treatment of 4 mg of dexamethasone before initiating anesthesia. Dexamethasone is known to suppress ACTH and cortisol levels. The objective was to find out whether the standard PONV-prophylaxis of 4 mg of dexamethasone has an effect on postoperative levels of cortisol in patients undergo...
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ea0032p910 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Report of a new case of the novel AIP p.R314W mutation in a Romanian sporadic acromegaly patient

Baciu Ionela , Galoiu Simona , Capatina Cristina , Botusan Ileana , Dumitrascu Anda , Ciubotaru Vasilie , Coculescu Mihail , Poiana Catalina , Radian Serban

Introduction: We have recently described a novel AIP mutation c.940C>T, p.R314W, in a young sporadic acromegaly patient.Aim: To present a new case of AIP p.R314W mutation and screening results of a Romanian control group for p.R314W.Patients and methods: One sporadic acromegaly patient, investigated by sequencing screening of all six AIP exons, following informed consent, as part of a sporadic pituitary adenoma cohort. 110 cont...
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ea0032p911 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The p.R16H AIP sequence variant is relatively frequent in Romanian sporadic pituitary adenoma patients

Radian Serban , Baciu Ionela , Capatina Cristina , Botusan Ileana , Ciubotaru Vasilie , Dumitrascu Anda , Coculescu Mihail , Poiana Catalina

Background: A large spectrum of AIP gene mutations has been identified in familial and sporadic pituitary adenomas (PA) with over 70 different mutations described to date. c.47G>A, p.R16H is an AIP exon 1 variant of unknown significance, its contribution to pituitary adenoma development being controversial.Aim: Characterization of p.R16H prevalence in a large Romanian cohort of PA patients and controls.Patients and methods: spo...
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ea0032p912 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Prevalance of cancer in acromegaly patients; a single center data

Gedik Arzu , Yilmaz Merve , Demir Tevfik , Yener Serkan , Bayraktar Firat , Eraslan Sevinc , Comlekci Abdurrahman

Introduction: The growth promoting effects of GH and IGF1 has lead to increasing number of cancer surveillence studies in acromegaly so far. We herein aimed to present the prevalance of cancer in acromegaly patients followed in our institution.Patients and design: We retrospectively analyzed medical records of 151 patients with acromegaly (83 females) followed in our department from 2001 to 2012.Results: Overall, cancer was detecte...
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ea0032p913 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Comparison of insulin tolerance test and ACTH stimulation test for evaluation of hypocortisolism in patients with acromegaly

Fougner Stine Lyngvi , Carlsen Sven M

Background: The insulin tolerance test (ITT) is considered the gold standard test for evaluating the ACTH–cortisol axis in patients with pituitary disease. However, the test requires time and personnel resources, and has clear contraindications. Therefore, an ACTH stimulation test is often performed instead.Objective: The objective was to compare the cortisol response acquired by ACTH stimulation and during ITT in patients with pituitary disease.</p...
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ea0032p914 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Functional hyperprolactinemia in polycystic ovary syndrome: incidence and correlation with hormonal parameters

Amzar Daniela , Balas Melania , Golu Ioana , Vizitiu Anda , Stana Loredana , Gurban Camelia , Zosin Ioana

Introduction: Polycystic ovary syndrome (PCOS) is associated with a complex altered hormonal profile. Functional mild hyperprolactinemia can be found in up to 25–30% of PCOS women. The aim of the study was to determine the incidence of hyperprolactinemia in PCOS patients and to correlate the prolactin values with hormonal and metabolic data.Material and methods: The study included 25 women, diagnosed with PCOS, according to Rotterdam criteria (mean ...
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ea0032p915 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Bone turnover decreases 6 months after acromegaly remission but still remains higher than in healthy population

Dusek Tina , Kraljevic Ivana , Polovina Tanja Skoric , Baretic Maja , Kastelan Darko

Introduction: The study was designed to assess the effects of remission of acromegaly on bone turnover.Methods: Twenty-eight patients with active acromegaly (14 women; age 48.0±9.8 years) were enrolled in the study. The control group comprised 28 age- and sex-matched healthy individuals. Bone turnover markers (osteocalcin, β-crosslaps, and bone alkaline phosphatase) were measured at enrolment and 6 months after achievement of disease remission....
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ea0032p916 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Skin flora in acromegaly

Gen Ramazan , Horasan Elif Sahin , Cinkir Umit , Gultekin Onur , Akbay Esen

Introduction: Recent study showed that patients with acromegaly have typical skin findings including increased sebum secretion, decreased transepidermal water loss, more alkaline, and colder skin surface correlated with serum GH and IGF1 levels.The aim of this study was to demonstrate the effect of functional skin changes on the skin flora in patients with acromegaly.Methods and designs: This case–control study was conducted i...
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ea0032p917 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effect of short- and long-term treatment with pasireotide on hemochrome in patients with Cushing's disease

Cozzolino Alessia , Simeoli Chiara , Trementino Laura , De Leo Monica , Vitale Pasquale , Iacuaniello Davide , Albano Aurora , Boscaro Marco , Colao Annamaria , Arnaldi Giorgio , Pivonello Rosario

Introduction: Generously supported by IPSEN)-->Glucocorticoids (GC) have a stimulatory effect on neutrophils and an inhibitory effect on the other leukocyte subpopulations. A potential stimulatory effect on erythropoiesis has been also hypothesized. The aim of our study was to evaluate the effect of pasireotide treatment on hemochrome parameters in patients with endogenous pituitary-dependent glucocorticoid excess or Cushing’s d...
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ea0032p918 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Evaluation of QT dispersion at the time of diagnosis and at the end of follow-up in acromegaly patients

Baser Husniye , Bayram Nihal Akar , Polat Burcak , Evrenos Berna , Ersoy Reyhan , Bozkurt Engin , Cakir Bekir

Background: Generously supported by IPSEN)-->In this study we have aimed to calculate the QT dispersion in acromegaly patients and reveal its correlation with GH and IGF1.Materials and methods: Forty-one acromegaly patients were enrolled in the study. Another 41 patients with similar age, sex and comorbid disease distrubition have constituted the control group. We have evaluated the electrocardiograms (ECG) of ...
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ea0032p919 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Transsphenoidal surgery, gamma-knife surgery and diabetes are the factors affecting the quality of life in acromegalic patients

Yalin Ayse Serap , Sancak Seda , Deyneli Oguzhan , Gunes Mutlu , Temizkan Sule , Yavuz Dilek Gogas , Akalin N. Sema

Generously supported by IPSEN)-->Acromegaly is a chronic disease with an important impact on patients, health-related quality of life (HRQoL). Acromegaly quality of life questionnaire (AcroQoL) is a disease-generated QoL questionnaire comprising 22 questions each having five possible responses scored 1–5, the maximum score of 110 reflecting best possible QOL, and quoted as a percentage. The 22 items break down into two categorie...
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ea0032p920 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The short synacthen test may be more sensitive than the glucagon stimulation test in assessing the hypothalamic–pituitary–adrenal axis: a retrospective audit

Blythe Richard , Elkashif Ismail , Malik Mohamed

Introduction: Generously supported by IPSEN)-->Insulin tolerance test (ITT) is considered as the gold standard assessment for hypothalamic–pituitary–adrenal axis (HPA) integrity. Short synacthen test (SST) is a relatively simple, low-cost and well tolerated first line test of HPA despite concerns regarding accuracy. The glucagon stimulation test (GST) is often used as an alternative to the ITT. Although less reliable, it is...
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ea0032p921 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Abstract withdrawn....
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ea0032p922 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Characterization of GH-producing pituitary adenomas according to responsiveness to thyrotropin-releasing hormone

Chin Sang Ouk , Kim Sung-Woon

Objective: Generously supported by IPSEN)-->The relationship between the paradoxical response of GH secretion after thyrotropin-releasing hormone (TRH) administration and tumor size has been the subject of only a few studies with conflicting results.Design: The aim of this study was to investigate how the paradoxical response of GH secretion to TRH changes according to tumor size.Methods:...
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ea0032p923 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Tumour volume reduction and GH/IGF1 control with lanreotide Autogel 120 mg every 28 days for treatment-naive acromegalic patients with GH-secreting pituitary macroadenoma: the PRIMARYS study

Caron Philippe , Bevan John , Clermont Antoine , Maisonabe Pascal

Introduction: Generously supported by IPSEN)-->Surgery is recognized first-line therapy for acromegalic patients but tumour size and GH/IGF1 control has also been observed after primary somatostatin analogue treatment. This is the first study of therapy with high-dose lanreotide Autogel over one year in a large cohort of treatment-naïve acromegalic patients.Methods: In this international, multicentre, open...
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ea0032p924 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Endoscopic transsphenoidal surgery for acromegaly: assessing the surgical outcome based on current criteria of remission

Zielinski Grzegorz , Witek Przemyslaw , Podgorski Jan

Introduction: Generously supported by IPSEN)-->Acromegaly is associated with increased morbidity and mortality, mainly due to cardiovascular and metabolic complications and higher risk of malignancy. The treatment of choice is selective transsphenoidal surgery (TSS). Successful removal of somatotroph adenoma normalizes GH and IGF1 levels, which improves the patients prognosis. The efficacy of TSS depends on the tumor volume, parasell...
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ea0032p925 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The influence of octreotide-LAR treatment on glucose homeostasis in acromegaly

Stelmachowska-Banas Maria , Zdunowski Piotr , Zgliczynski Wojciech

Introduction: Generously supported by IPSEN)-->Impaired glucose tolerance and insulin resistance are frequently associated with acromegaly. The aim of this study was to assess the effect of octreotide-LAR treatment on glucose homeostasis in acromegalic patients.Patients and methods: In this prospective study 16 naïve acromegalic patients were studied before and after 3-month therapy of octreotide-LAR (20 m...
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ea0032p926 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Somatotropin and IGF1 levels at diagnose and after surgery in acromegalic patients: is it possible to predict the likelihood of cure at diagnosis?

Belo Sandra , Nogueira Claudia , Magalhaes Angela , Vinha Eduardo , Pereira Josue , Carvalho Davide

Introduction: Generously supported by IPSEN)-->Elevated levels of somatotropin (ST) and IGF1 in acromegalic patients are associated with high morbidity and mortality. The normalization of ST and IGF1 allows the reversal of most of their negative effects.Objective: To evaluate characteristics present at diagnosis, predictive of cure, after surgery, in patients with ST-producing tumors.Meth...
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ea0032p927 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Therapeutic response to recombinat somatropin in children with isolated deficiency of GH

Belo Sandra , Nogueira Claudia , Corujeira Susana , Costa Carla , Castro-Correia Cintia , Fontoura Manuel

Introduction: Generously supported by IPSEN)-->Treatment with recombinant ST is subject to strict criteria. Differences in the response to therapy based on the maximum level of ST in diagnostic tests (ST ≤5 vs ST >5 ng/ml), could predict whose patients would benefit more from therapy.Purpase: Assess differences in the response to therapy with rST in patients with IDGH.Methods: S...
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ea0032p928 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Thyroid cancer in patients with acromegaly

Balcere Inga , Peculis Raitis , Klovins Janis , Pirags Valdis

Generously supported by IPSEN)-->It is known that acromegaly is associated with increased risk of benign and malignant tumours. Previous studies show the prevalence of nodular thyroid disease in 40–70% of patients with acromegaly, and a 5–7% prevalence of thyroid cancer in these patients, which is higher compared to the general population.Latvian Cancer Register data show an incidence of thyroid cance...
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ea0032p929 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Therapeutic role of dopamine-agonists in ESRF-induced hyperprolactinaemia

Wijetilleka Sajini , Parvathy Chandra , Ogilvie Arla , Kong Chantal

Generously supported by IPSEN)-->Moderate hyperprolactinaemia (<1000 mU/l) is a common abnormal biochemical finding in patients with end-stage renal failure (ESRF). The underlying pathophysiological mechanism is thought to be due to a combination of increased prolactin secretion as well as delayed renal clearance. There are no current clear guidelines for the treatment of ESRF-induced symptomatic hyperprolactinaemia but renal tra...
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ea0032p930 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

A rare case of pituitary infarction in an 11-year-old pre-pubertal girl with pituitary autoantibodies to piccolo

Crock Patricia , Maltby Vicki , Smith Casey J A , Bensing Sophie , Ludecke Dieter K , Kampe Olle

Introduction: Generously supported by IPSEN)-->Pituitary infarction is rare in the paediatric age. In adolescents and adults it is often secondary to haemorrhage into an underlying lesion such as pituitary adenoma or cyst. Lymphocytic hypophysitis is rare in children and usually peri-tumoral due to germinoma, craniopharyngioma or Rathke’s cyst and often associated with hypopituitarism and diabetes insipidus.<p class="abstext...
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ea0032p931 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Idiopathic isolated ACTH deficiency presenting with severe hyponatraemia

Drescher Tilman , Ackermann Christoph , Batscher Irene , Krull Ina , Brandle Michael , Bilz Stefan

Introduction: Generously supported by IPSEN)-->Acquired isolated ACTH deficiency with normal secretion of the remaining pituitary hormones is a rare condition in the absence of exposure to exogenous glucocorticoids. The aetiology is assumed to be autoimmune in most adult cases with traumatic brain injury and radiation exposure being rare causes. Pituitary transcription factor mutations may be identified in congenital and childhood on...
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ea0032p932 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Diagnostic features and surgical therapy of acromegalic patients: experience of the last three decades

Ferrante Emanuele , Sala Elisa , Locatelli Marco , Mantovani Giovanna , Malchiodi Elena , Carrabba Giorgio , Gaini Sergio Maria , Lania Andrea Gerardo , Spada Anna , Beck-Peccoz Paolo

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare and insidious disease associated with an increased morbidity and mortality. Trans-sphenoidal (TNS) surgery remains the primary therapeutic option, in particular for intrasellar microadenomas and noninvasive macroadenomas. Aims of this study were to describe diagnostic features and to verify the impact of TNS surgery on treatment of acromegaly over three decades, befo...
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ea0032p933 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Pituitary tumours and epilepsy

Akkache Lina , Daffeur Katia , Chentli Farida

Introduction: Generously supported by IPSEN)-->Epilepsy is a heterogeneous condition with different aetiologies including genetics, cerebral trauma, toxic exposures, infection, vascular diseases and neoplasms. Among the last ones, pituitary tumours (PT) are rarely responsible of convulsions, except when they are very large invading the nervous system. Our aim is to analyze the conditions under which the epilepsy appears and disappear...
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ea0032p934 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Predictors of hormonal status after pituitary surgery

Taibo Rocio Villar , Casariego Alfonso Vidal , Pomar Maria D Ballesteros , Martin Rosa Alvarez San , Fernandez Javier Fernandez , Arino Teresa Ribas , Risueno Elena Galan , Rodriguez Isidoro Cano

Introduction: Generously supported by IPSEN)-->Surgical treatment of pituitary adenomas (PA) may affect hormone situation.Objective: To evaluate the frequency of hypopituitarism and investigate the potential predictors of worsening or improving pituitary function after PA surgery.Methods: Retrospective analysis of all PA operated in our hospital between 2001 and 2010.<p class="abstext...
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ea0032p935 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Fetuin-A can be used as a marker of acromegaly

Topsakal Senay , Akin Fulya , Yaylali Guzin , Turgut Sebahat , Herek Duygu , Yerlikaya Emrah , Ayada Ceylan

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare, chronic disorder, with classical clinical features caused by excess GH and consequent raised levels IGF1 and is associated with increased morbidity and mortality. Early diagnosis of the disease is very important for patient survival. Fetuin-A is a plasma glycoprotein that is produced by hepatocytes and it is the most important systemic calcification inhibitor. The p...
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ea0032p936 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Evaluation of body weight, insulin resistance, leptin and adiponectin levels in premenopausal women with hyperprolactinemia

Atmaca Aysegul , Bilgici Birsen , Ecemis Gulcin , Tuncel Ozgur

Introduction: Generously supported by IPSEN)-->The effects of hyperprolactinemia on metabolic parameters are not conclusive and a few data evaluating adiponectin levels in prolactinoma and idiopathic hyperprolactinemia exist. The aim of this study is to evaluate effects of hyperprolactinemia on body weight, insulin resistance, β cell function, leptin and adiponectin levels in premenopausal women with hyperprolactinemia.<p cl...
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ea0032p937 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Carbohydrate metabolism in acromegaly and treatment impact

Biagetti Betina , Valladares Silvia , Arnez Lorena , Dalama Belen , Obiols Gabriel , Mesa Jordi

Introduction: Generously supported by IPSEN)-->Carbohydrate metabolism (CHM) is impaired in over 30% of acromegalic patients. Natural history of acromegaly and treatment modalities, i.e. surgery, somatostatin analogues (SSA) and pegvisomant, may impact in a different way on CHM.Aim: To assess CHM alterations (impaired fasting glucose (IFG) and diabetes mellitus (DM)) in acromegaly and their relationship with cl...
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ea0032p938 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Pituitary apoplexy in clinically nonfunctioning pituitary adenomas: experience of a single center

Karagiannis Apostolos , Boufas Dimitrios , Tzioras Konstantinos , Seretis Andreas , Vryonidou Andromachi

Introduction: Generously supported by IPSEN)-->Clinically nonfunctioning pituitary adenomas (CNFPA) represent 25–50% of all pituitary lesions. They may be asymptomatic and discovered incidentally or they may be diagnosed due to visual impairment or symptoms of pituitary hormone insufficiency. There is little data on apoplexy frequency in the CNFPA.The aim of our study was to assess the frequency of CNFPA a...
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ea0032p939 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Pituitary abscess: a possible cause of hypopituitarism

Belo Sandra , Magalhaes Angela , Carvalho Davide

Background: Generously supported by IPSEN)-->Pituitary abscess is a rare but potentially fatal entity. It represents ~0.2–1% of all pituitary lesions. The symptoms are usually nonspecific. The proper interpretation of imaging studies is of extreme importance to the differential diagnoses.Case: Man, 40 years old, begins complaining of occipital headache (25.04.2011), initially with good response to treatmen...
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ea0032p940 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Cushing's disease recurrence after pregnancy

Yaylali Guzin Fidan , Akin Fulya , Yerlikaya Emrah , Topsakal Senay , Herek Duygu

Introduction: Generously supported by IPSEN)-->Pregnancy is rare in patients with Cushing’s syndrome (CS) because of hypercortisolemia, hyperandrogenemia, and/or hyperprolactinemia. Diagnostic tests for CS have become less reliable due to the physiological changes in the hypothalamo-pituitary adrenal (HPA) axis during gestation. Some of these changes may persist until the 5th postpartum week. We report a case of Cushing...
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ea0032p941 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Clinical presentation, treatment approach and outcomes of patients with prolactinomas in real-life clinical practice: a single center experience

Vicente Almudena , Satre Julia , Zaballos Florentino , Luque Ines , Luque Alessandra , Castro Enrique , Maqueda Esther , Marco Amparo , Lopez Jose

Introduction: Generously supported by IPSEN)-->Prolactin (PRL) -secreting adenomas are about 40% of all pituitary adenomas. Their clinical symptoms are mainly related to development of secondary hypogonadism and/or tumor mass effects. Dopamine agonists (DA) are first-line drugs for prolactinoma patients due to their effectiveness in normalizing PRL levels and shrinking tumour mass. Surgery is an option for DA failure or tumour mass e...
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ea0032p942 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Clinical characteristics of patients with congenital hypopituitarism in advanced age

Doknic Mirjana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Popovic Vera

Background: Generously supported by IPSEN)-->Hypopituitarism is considered to be a risk factor for cardiovascular disease and early death in humans. However, some studies showed that most patients with isolated GH deficiency or combined pituitary hormonal deficiency due to gene mutations (PROP 1, GH receptors gene, GH-1 gene) can survive to advanced age.Aim: To collect clinical data on patients with congenital ...
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ea0032p943 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Pituitary abscess after cabergoline treatment of a prolactinoma in a 56 year old male: case report and review of the literature

Voellger Benjamin , Mawrin Christian , Schneider Thomas

Objective: Generously supported by IPSEN)-->Abscesses in pituitary adenomas are rare. Continuous progression and haematogenous spread of infections are considered the main pathogenic mechanisms. A standard therapeutic regimen does not exist.Methods: We report on the case of a 56-year-old male who had been treated with cabergoline for a macroprolactinoma for 4.5 years. The patient presented to our emergency room...
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ea0032p944 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Tuberous sclerosis: an uncommon cause of hyperprolactinemia

Kota Sunil Kumar , Meher Lalit Kumar , Jammula Sruti , Modi Kirtikumar D

Objective: Generously supported by IPSEN)-->To report a case of tuberous sclerosis presenting with hyperprolactinemia.Methods: Clinical, laboratory and radiographic data are reported on a 26-year-old female presenting with galactorrhea and menstrual irregularities.Case report: A 26-year-old female with no premorbidities presented with complaints of galactorrhea for the past 10 days and me...
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ea0032p945 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Hemiparesis and hemiplegia as clinical presentation in subjects with pituitary tumours

Haddad Meriem , Daffeur Katia , Kalafate Nadia , Akkache Lina , Chentli Farida

Introduction: Generously supported by IPSEN)-->Pituitary tumours are known to cause headaches and visual troubles by compressing pituitary adjacent structures. Pressure on more distant structures is exceptional. In very large tumours such as prolactinomas, mixed adenomas or craniopharyngiomas, hydrocephalus, convulsions, memory troubles and even unconsciousness can be observed, but to our best knowledge motor deficits, such as hemipl...
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ea0032p946 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Relation with carotid intima media thickness and procalcitonin in acromegalic patients

Topsakal Senay , Akin Fulya , Turgut Sebahat , Herek Duygu , Yaylali Guzin , Yerlikaya Emrah , Ayada Ceylan

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare, insidious, and potentially life-threatening condition. Patients with acromegaly have an increased morbidity and mortality for cardiovascular diseases. However, data on coronary heart disease and atherosclerosis are controversial in patients with acromegaly. Measurement of carotid intima media thickness (cIMT) with carotid doppler ultrasonography is a useful determin...
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ea0032p947 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The role of octreotide LAR treatment on BMI in patients with acromegaly

Velija-Asimi Zelija

Objectives: Generously supported by IPSEN)-->It is known that the obesity and insulin resistance are an integral part of acromegaly. The aim of study was to evaluate the role of octreotide LAR treatment on BMI in patients with acromegaly.Methods: Sixteen patients with acromegaly diagnosed at Endocrinology Clinic in Sarajevo (10 females and 6 males, mean age 53.4±6.3 years, age range 38–65 years, six p...
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ea0032p948 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effect of somatotropin and IGF1 secretion on glucose metabolism: diabetic ketoacidosis as first manifestation of acromegaly

Santos Maria Joana , Almeida Rui , Marques Olinda

Generously supported by IPSEN)-->Insulin and somatotropin (GH) have opposite effects in glucose metabolism. GH increases the production of glucose through lypolisis and inhibits hepatic and peripheric neoglucogenesis induced by insulin. When insulin secretion is insufficient to overcome insulin resistance, intolerance to glucose or diabetes appears. Drugs used in the treatment of acromegaly also influence glucose metabolism: SSA decr...
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ea0032p949 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Prolactinoma: does the size affect the signs?

Abdesselem Haifa , Haouat Emna , Salem Leila Ben , Laanani Amira , Turki Zinet , Slama Claude Ben

Introduction: Generously supported by IPSEN)-->Prolactinoma is the commonest pituitary adenoma. The aim of this study was to compare clinical, biological and radiological characteristics in microprolactinoma and macroprolactinoma.Patients: This retrospective study included 33 patients with prolactinoma. The tumor was a microadenoma (<1 cm) in 27.3% (n=9) and a macroadenoma in 72.7% (n=24) ...
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ea0032p950 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Diagnosis and treatment of a population of acromegalic patients

Nogueira Claudia , Belo Sandra , Pereira Josue , Vinha Eduardo , Magalhaes Angela , Carvalho Davide

Introduction: Generously supported by IPSEN)-->Acromegaly is a chronic disease caused by GH hypersecretion resulting in increased IGF1 levels. The actions of these hormones result into a broad spectrum of clinical manifestations.Objective: To evaluate clinical and analytical parameters, imaging, and treatment outcome in a population of acromegalic patients.Methods: Retrospective study of ...
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ea0032p951 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Syndrome of inappropriate antidiuresis due to low dose hydrochlorothiazide use in a patient after transsphenoidal surgery for pituitary adenoma

Mikhaylova Daria , Vorotnikova Svetlana , Pigarova Ekaterina , Grigor'ev Andrey , Dzeranova Larisa

Introduction: Hyponatriemia is one of severe postoperative water-electrolyte disturbances. This condition is usually caused by syndrome of inappropriate secretion of antidiuretic hormone or cerebral salt-wasting syndrome which require different treatment approaches.Case presentation: A 61-year-old woman was referred to tertiary care center with non-functioning pituitary macroadenoma. The patient had been suffering from headaches for 4 later years and had...
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ea0032p952 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

An acromegalic patient with giant tumor

Ecemis Gulcin Cengiz , Kan Elif Kilic , Bahadir Cigdem Tura , Atmaca Aysegul , Atmaca Hulusi , Colak Ramis

Introduction: Acromegaly is a disease caused by excessive secretion of GH. The cause of acromegaly is GH secreting pituitary adenoam in 99% of the cases. It is estimated that 5% of pituitary adenomas become invasive and may grow to gigantic sizes (>4 cm in diameter). Here, we present a 31 years old acromegalic woman with a delayed diagnosis of a giant invasive pituiatary adenoma.Case report: A 31-year-old woman admitted to our hospital for oligomenor...
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ea0032p953 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Hyperprolactinemia in women

Kushnir Liudmila

The aim of this study was to determine the structure of the primary incidence of hyperprolactinemia among the female population of the city during 2011. 114 medical cards of women with hyperprolactinemia were researched and analyzed. It was determined that the mean age of the case detection was 28.9 years (σ=8.2). The main clinical features were the disturbances of menstrual period (41.2%), infertility (26.3%), galactorrhea (21.9%) and the changes of the body wei...
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ea0032p954 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Radiotherapy in the management of pituitary functioning adenomas: a single-center experience

Moreno Carolina , Paiva Isabel , Gomes Leonor , Ruas Luisa , Gouveia Sofia , Saraiva Joana , Guelho Daniela , Carvalheiro Manuela , Carrilho Francisco

Introduction: Radiation therapy is an effective treatment for relapsing or recurrent pituitary functioning adenomas, providing tumor volume control and hormone secretion normalization. However, there are several secondary effects to consider.Aims: To assess the efficacy of radiotherapy in the management of patients with acromegaly and Cushing’s disease (CD) treated in our Department, and the prevalence of radiation secondary effects.<p class="ab...
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ea0032p955 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Atypical McCune–Albright syndrome associated with GH secreting pituitary adenoma

Pemovska Gordana , Volkanovska - Ilijevska Cvetanka , Krstevska Brankica , Ahmeti Irfan

McCune–Albright syndrome (MAS) is characterized by fibrous dysplasia (FD), cutaneous cafe-au-lait pigmentation and autonomous hyper-secretory endocrinopathies. Association of acromegaly with MAS is very rare. We present a case of a 35-year-old men with MAS, diagnosed with poly-ostotic fibrous dysplasia at the age of 12, no history of premature puberty, with GH secreting cystic macroadenoma 40×35×45 mm big and clinical picture of acromegaly, hypopituitarism and b...
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ea0032p956 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Hyponatremia as a first sign of panhypopituitarism: empty sella

Dokupilova Adriana , Kollerova Jana , Payer Juraj

Introduction: Hyponatremia is the most common disorder of electrolytes encountered in clinical practice, occurring in up to 15–30% of both acutely and chronically hospitalized patients. Although most cases are mild and relatively asymptomatic, it is important clinically because: i) acute severe hyponatremia can cause substantial morbidity and mortality, ii) mortality is higher in patients with hyponatremia who have a wide range of underlying diseases and iii) overly rapid...
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ea0032p957 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Somatotrop adenomas: comparison between men and women in algerian population

Daffeur Katia , Haddad Meriem , Saraoui Fatima , Akkache Lina , Kalafate Nadia , Meskine Djamila , Chentli Farida

Introduction: Pituitary adenomas in general are deemed to be more aggressive in males. Our aim is to analyze somatotrop adenomas (SA) characteristics and neurological complications. In the second time we will compare male and female cases.Subjects and methods: In this retro-and prospective study, 112 pure and mixed SA diagnosed between 1980 and 2012 were analyzed. They all had hormonal assessment (GH before and after OGTT±IGF1, PRL, cortisol, ACTH, ...
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ea0032p958 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Non functionning pituitary adenomas

Kalafate Nadia , Daffeur Katia , Safer Amel , Haddad Meriem , Akkache Lina , Chentli Farida

Introduction: Non functioning pituitary adenomas (NFPA) frequency varies from 15 to 30% among all pituitary adenomas. Some authors think they are more aggressive and at risk of pituitary apoplexy. Our aim is to analyze their characters and their complications.Subjects and methods: It is a retrospective study that takes in account 37 subjects having a NFPA and recruited from 2005 to 2012. Among this group only 13 have been operated on and had immunochemic...
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ea0032p959 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Assessment of bone mineral density in patients with Sheehan’s syndrome

Kilicli Fatih , Acibucu Fettah , Dokmetas Hatice Sebila

Introduction: Although the cause and effect relationship between the hypophyseal deficiency and osteoporosis is known well, the number of studies concerning bone mineral density (BMD) in patients with Sheehan’s syndrome (SS) are scarce. We aimed to investigate the relationship between BMD and deficient hormones in patients with newly-diagnosed Sheehan’s syndrome.Material and methods: Thirty-four patients with SS and age-gender-weight matched 22...
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ea0032p960 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Giant invasive macroprolactinoma 2: case report

Hasbellaoui Fella , Amokrane Samia , Achir Samia , Bouraoui Ibtissem , Semrouni Mourad

Introduction: Prolactinoma are the most frequent pituitary adenoma, considered benign tumor and well respond to medical treatment, but sometimes, in men prolactinoma may be invasive and aggressive occurring neurological signs.Case 1: Male 53 years old, went to ophtalmology consulting for progressive vision problems associated with headaches from more than a year but denied. On examination visual field showed poor vision in left eye and temporal defect on...
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ea0032p961 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Pituitary hyperplasia secondary to primary hypothyroidism in a child with mosaic trisomy 21

Belhimer Faiza , Chentli Farida

Introduction: Pituitary hyperplasia (PH) is relatively a rare condition in children. As in adults, it can be secondary to a long-standing primary hypothyroidism and can sometimes be mistaken with a pituitary macro-adenoma as in the following observation:Case report: Herein, authors describe a girl aged 10 years old sent by her neurosurgeon for pre operative hormonal exploration of a pituitary macro adenoma measuring 13 mm in height. This one was discover...
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ea0032p962 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Can apelin level used as a marker of active and inactive acromegaly?

Topsakal Senay , Akin Fulya , Yaylali Guzin , Turgut Sebahat , Herek Duygu , Yerlikaya Emrah , Ayada Ceylan

Introduction: Acromegaly is a rare disease that is most often caused by a GH secreting pituitary tumor. Apelin, a newly discovered peptide known as an endogenous ligand for its receptor (APJ) is a cardiac positive inotropic factor that has also hypotensive effects. The apelin and its receptor functions have not entirely been understood yet. The physiological importance of apelin, in acromegaly remains obscure.The aim of this study was to investigate the ...
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ea0032p963 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Pasireotide in treatment of Cushing’s disease: our first experience

Vanuga Peter , Kentos Peter , Pavai Dusan , Pura Mikulas

Background: Although the excision of ACTH-producing tumors is the principal treatment for Cushing’s disease (CD), pharmacologic treatment has a well-established role. As corticotroph adenomas express somatostatin (SST) receptors (SSTRs), pasireotide – a pluripotent somatostatin analogue, acting on four of five SSTRs has a potential role in treatment of CD among various medical agents.Case report: We report a 39-year-old female with recurrence o...
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ea0032p964 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Corticotroph adenoma and fertility

Brakni Lila

Introduction: The occurrence of a pregnancy in a woman with a corticotroph adenoma is rare, <25 observations have been reported.Maternal complications are especially hypertension (60–75%) gestational diabetes (25%) and preeclampsia in 10%.Fetal complications are spontaneous miscarriage, preterm birth and intrauterine growth retardation.Observation: We report a case of a 30 years old female followed f...
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ea0032p965 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Central hypothyroidism and adjusted thyroxine dose study (CHATS): impact of increasing free thyroxine levels in patients with hypopituitarism

Minder Anna-Elisabeth H , Jostel Andreas , Higham Claire E , Ryder W David J , Trainer Peter J , Shalet Stephen M

Introduction: Patients with pituitary deficiencies suffer from impaired quality of life regardless of substitution therapy with hydrocortisone, thyroxine (T4), sex hormones or GH. Central hypothyroidism (CH) is difficult to diagnose and treat because symptoms are non-specific and TSH-levels cannot be used for assessment. There is no consensus for the fT4-goal of thyroxine-replacement in patients with CH.Aim: To determine the impact ...
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ea0032p966 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

A retrospective-prospective study of the effect of octreotide LAR in acromegalic patients

Pemovska Gordana , Volkanovska Ance , Jovanoska Biljana , Shubeska-Stratrova Slaviva

Objective: Surgery is considered first-line treatment for pituitary GH secreting macroadenoma. Since surgical removal of the pituitary tumor is subtotal, medical treatment has become the mainstay of acromegaly. The aim of our study was to assess the effect of octreotide LAR (OCT-LAR) therapy in patients with acromegaly.Patients and methods: Ten acromegalic patients were treated with OCT-LAR 20 mg/28 days. The effect was evaluated after 12 months of treat...
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ea0032p967 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Craneopahrygioma: a false enemy

Lorenzo Jaime , Boente Ruth , Santos Eloisa , Sas Manuel

Background: Craneopharygioma is a rare solid or mixed tumor, that arise from remnants of Rathke’s pounch. Usually they are in the suprasellar region and very few of them arise from the sella. Bimodal (5–14 years old and 50–75) and slow growth are typical characteristics as well.Clinical case: A 20 years old boy was refered to endocrine clinic by hypothyroidism, hypotension, and sexual dysfunction. Central hypothyroidism, hypogonadotropic h...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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