Endocrine Abstracts

During the last decade induced overexpression of defined transcription factors has been shown to have a driving effect on the differentiation of embryonic stem cells (ESCs) into many specific cell types. Nevertheless, the generation of protocols promoting a coordinate self-assembly of differentiated cells into distinct morphological units with also functional properties reminiscent of organs and tissues in vivo are still very sparse. Recently, we have reported the gen...

In males androgens are primarily made by testicular Leydig cells and act as essential regulators of both fetal masculinization and adult reproductive function. The impact of androgens on gene transcription is largely mediated by the androgen receptor (AR), a member of the steroid hormone super-family of ligand activated transcription factors. AR is expressed widely throughout the body, including several key somatic cell-types in the testis. Although we have known for many year...

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