Endocrine Abstracts

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Nonalcoholic fatty liver disease (NAFLD) is becoming a master component of the epidemic of obesity and metabolic syndrome worldwide due to excessive caloric intake. The spectrum of NAFLD ranges from simple fatty liver with benign prognosis to a potentially progressive form, nonalcoholic steatohepatitis (NASH), which may lead to liver fibrosis and cirrhosis resulting in increased morbidity and mortality. Development of hepatic steatosis and its progression to steatohepatitis ma...

When energy is needed, white adipose tissue (WAT) provides fatty acids (FA) for use in peripheral tissues via stimulation of fat cell lipolysis. FA have been postulated to play a critical role in the development of obesity-induced insulin resistance, a major risk factor for diabetes and cardiovascular disease. However, whether and how chronic inhibition of fat mobilization from WAT modulates insulin sensitivity remains elusive. Hormone-sensitive lipase (HSL) participates in th...