Endocrine Abstracts (2013) 32 P280 | DOI: 10.1530/endoabs.32.P280

Fibrous variant of Hashimoto's thyroiditis: development of neck fibrosis and mediastinal fibrosis

Albert Makarov1,2, Violetta Arzhakova1,2, Peter Neustroev1 & Elena Makarova2


1North-Eastern Federal University named after M K Ammosov, Yakutsk, Russia; 2National Center for Medicine, Yakutsk, Russia.


Immunoglobulin G4-related disease (IgG4-RD) is now a widely recognised multi-organ system disease characterised by elevated serum and tissue concentrations of IgG4. Two forms of thyroid involvement in IgG4-RD have been described, including Reidel’s thyroiditis (IgG4-related thyroid disease) and the fibrous variant of Hashimoto’s thyroiditis.

Objective: To describe a case of the development of massive neck fibrosis and mediastinal fibrosis in a patient with the fibrous variant Hashimoto’s thyroiditis.

Methods and case presentation: In January 2012, a 59-year-old woman with a 1-year history of subclinical hypothyroidism due to Hashimoto’s autoimmune thyroiditis was admitted to our department, presenting with a swelling in the anterior region of the neck, dyspnea, dysphagia, fatigue. The tumor progressed quickly to a ecklarge, stony hard mass on the anterior neck region. Analysis: TSH, 0.42 mU/ml, FT4, 13.90 pmol/l; AbTPO, 133.92 UI/ml, erythrocyte sedimentation rate (ESR), 58 mm/h; Echo-guided FNAB confirmed the diagnosis of Hashimoto thyroiditis and neck fibrosis. A computed tomography (CT) revealed a fibrotic mass located at the anterior-inferior aspect of the neck and mediastinum with displacement of the tracheal lumen and stenosis of oesophagus. We started therapy with prednisolone 60 mg daily and L-thyroxine substitution therapy. The follow-up lasted for 12 months. After 1 month of corticosteroid therapy, the patient had no compression symptoms. The treatment with prednisolone led to a significant subjective improvement and objective changes (a significant decrease of neck and mediastinal fibrosis), confirmed by regular clinical examinations, ultrasonography and computed tomography of the neck and mediastinum. Now the patient is in good health, undergoing a therapy by prednisolone 5 mg daily.

Conclusion: We have reported an unusual case of development of the massive neck fibrosis and mediastinal fibrosis in a patient with Hashimoto’s thyroiditis. which showed good response to steroid treatment. It is important for the physician to recognize the presence of mediastinal fibrosis in the presence of fibrous variant of Hashimoto’s Thyroiditis and initiate steroid therapy for resolution of both diseases.

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