Endocrine Abstracts (2013) 32 P801 | DOI: 10.1530/endoabs.32.P801

Adipocyte dysfunction in pediatric obesity

Iuliana Gherlan, Suzana Vladoiu, Andra Caragheorgheopol, Florin Alexiu, Sorina Schipor, Mihaela Giurcaneanu, Adriana Padure, Andreea-Cristiana Brehar, Cristina Dumitrescu, Camelia Procopiuc & Constantin Dumitrache

‘C.I.Parhon’ National Institute of Endocrinology, Bucharest, Romania.

Background: Obesity is associated with adipocyte dysfunction, characterized by an impaired secretion of adipokines, which leads to a systemic inflammatory status.

Aim: To characterize adipokines’ profile in a group of obese children and adolescents.

Method: A case–control study comparing 102 obese children (BMI ≥95th percentile; aged 10–18 years) to a group of 43 healthy controls matched for age and pubertal status.

Adiponectin, leptin, resistin, TNFα, AFABP and lipocalin-2 were measured using ELISA method and were correlated with traditional clinical and biochemical biomarkers of the metabolic syndrome (BMI, waist circumference, blood pressure, fasting glycaemia and insulinemia, and lipids profile).

Results: The plasmatic levels of leptin, resistin, AFABP, lipocalin-2, and IL6 were significantly higher while the adiponectin plasmatic levels were significantly lower in the obese group compared to the control group; TNFα was not different between groups.

Adiponectin, leptin, AFABP, and resistin were significantly correlated to BMI, blood pressure, and insulin resistance biomarkers (negative correlation for adiponectin, positive correlations for others adipokines); there was also a parallel variation of the previous mentioned adipokines and HDL-cholesterol, positive for adiponectin and negative for leptin, resistin, and AFABP.

IL6 and lipocalin-2 were positively correlated only to BMI, while TNFα was positively correlated to systolic blood pressure.

Conclusions: Pediatric obesity is already associated with an altered production of adipokines, which participates in the pathogenesis of obesity-associated comorbidities.