ECE2013 Poster Presentations Growth hormome IGF axis – basic (16 abstracts)
Pilot study of nocturnal TSH surge in idiopathic short stature
Fadila Gadallah , Salwa Sedeek , Khaled Makboul , Rania Abd El Baki , Caroline Adel , Maged El-Setouhy & Magdy Abdel Aziz
Faculty of Medicine, Ain Shams University Hospitals, Cairo, Egypt.
Background: TSH surge is the most sensitive test currently available for confirming the diagnosis of central hypothyroidism, a hidden cause of idiopathic short stature.
Objective: Studying the nocturnal TSH surge in children with the idiopathic shot stature.
Patients and method: The study included 30 healthy children (10–18 years) as a control group and 30 children of matching age and sex with ISS as a patients group. TSH was measured for each subject at each of 1000, 1900, and 2200 h peak and nadir levels were determined, and TSH surge ((peak–nadir)/nadir) was expressed as percent rise over nadir.
Results: 33.33% of patients with idiopathic short stature had central hypothyroidism with blunted nocturnal TSH surge. 36.67% of the patients had unrecognized mild primary hypothyroidism with normal nocturnal TSH surge. The remaining 30% rested under the cover of the term ‘idiopathic’ short stature and had a normal nocturnal TSH surge, thus there was a significant percentage of central hypothyroidism in idiopathic shot stature in comparison with control group who all had normal nocturnal TSH surge.
Conclusion: The study of nocturnal TSH surge in idiopathic shot stature is useful to diagnose and avoid missing central hypothyroidism and mild primary hypothyroidism.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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