Endocrine Abstracts

Induced overexpression of defined transcription factors has been shown to have a directing effect on the differentiation of embryonic stem cells (ESCs) into specific cell types. Nevertheless, protocols promoting coordinated self-assembly of differentiated cells into distinct morphological units with functional properties reminiscent of organs and tissues in vivo are still very sparse. Our group recently reported efficient rescue of hypothyroidism in athyroid mice tran...

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Most of the oncogenic events in thyroid cancer are known, and the pathways which govern thyroid cell proliferation have been exquisitely mapped. However, existing knowledge does not fully explain the genetic complexity of thyroid cancer, or reveal whether tumours are likely to be benign, malignant, or resistant to treatment. Whilst mutations and chromosomal rearrangements are central to the aetiology of DTC, the altered expression of proto-oncogenes and tumour suppressor genes...